Gelnique formulation is a colorless, fragrance free solution that contains some alcohol. It dries up quickly once applied on the skin. The dose of Gelnique is 1 g (1 ml) applied once a day. The gel may be applied on the thighs, abdomen, upper arms, or shoulder. Once Gelnique is applied on skin, there is constant absorption over the next 24 hours, resulting in a constant effect with minimal side effects.
Further studies have shown that absorption of Gelnique from the skin is not affected by showering 1 hour later or by applying sunscreen 30 minutes before or after applying the drug.
Gelnique is not recommended for use in individuals who have or at risk of developing
- urinary retention
- men with prostatic hypertrophy
- individuals with gastroparesis
- individuals with uncontrolled narrow angle glaucoma
- individual with allergy to the agent
Other medical disorders where the oxybutynin should be used with caution is in individuals with impairment of liver, kidney, muscle paralysis, ulcerative colitis, constipation, or reflux.
Because the gel can be transferred from human to human by vigorous skin to skin contact at the application site, washing of hands and avoidance of close contact with children is recommended for the first few hours. Since the drug is made in an alcoholic solution, one should avoid smoking, or close contact with heating or fire appliance until the gel is completely dry.
Thursday, April 30, 2009
Oxybutynin Gel 10% for Overactive Bladder
Overactive bladder affects nearly 33 million individuals in North America. Both men and women are equally affected, but more severe symptoms occur much early in women. Symptoms of overactive bladder include urinary urgency, frequency, and frequent urination at night. These symptoms often lead to a poor quality of life, depression, isolation, and long term disability. There are many treatments for overactive bladder but most pills also have side effects.
Recently, the FDA approved use of Oxybutynin chloride gel (10%) for the treatment of overactive bladder. Oxybutynin (Gelnique) acts like an anti spasmodic agent and offers patients with overactive bladder a better method to control their disorder. By relaxing the bladder muscles, oxybutynin helps diminish the strong urge to urinate all the time.
When Gelnique was evaluated in a recent clinical trial, it was shown to be quite efficacious and had minimal side effects. Applying the drug as paste led to better patient compliance. In a recent 12-weeks double blind trial, the gel was compared to a sugar formula and most patients has decreased incontinence episodes, less urinary frequency and urgency.
Oxybutynin is applied on skin as a gel and thus it bypasses the liver. This leads to much fewer side effects – that are commonly seen when the drug is administered as a pill. Most patients in the trial had significantly fewer episodes of dry mouth and constipation when the topical formula was used.
Recently, the FDA approved use of Oxybutynin chloride gel (10%) for the treatment of overactive bladder. Oxybutynin (Gelnique) acts like an anti spasmodic agent and offers patients with overactive bladder a better method to control their disorder. By relaxing the bladder muscles, oxybutynin helps diminish the strong urge to urinate all the time.
When Gelnique was evaluated in a recent clinical trial, it was shown to be quite efficacious and had minimal side effects. Applying the drug as paste led to better patient compliance. In a recent 12-weeks double blind trial, the gel was compared to a sugar formula and most patients has decreased incontinence episodes, less urinary frequency and urgency.
Oxybutynin is applied on skin as a gel and thus it bypasses the liver. This leads to much fewer side effects – that are commonly seen when the drug is administered as a pill. Most patients in the trial had significantly fewer episodes of dry mouth and constipation when the topical formula was used.
Tuesday, April 28, 2009
How long can one take Viagra?
The two drugs for erectile dysfunction are Viagra and cialis. Recently there was an announcement that perhaps when these drugs were taken for a long time, it could lead to vision loss. However, now there is good news. If you got the money to buy Viagra or cialis, you can safely continue to use these two drugs without having to worry about your vision.
There was recent concern that use of drugs like Viagra could lead to impairment of vision or decreased vision at night. Some individuals also complained of blue vision. A recent study revealed that both drugs are safe and do not cause a higher vision loss compared to people who do not take Viagra. A well-controlled study did follow 244 men who took cialis or Viagra daily for 6 months (lucky guys had free Viagra because of the study). The study carefully analyzed vision and found no difference between those who took the drugs and those who took a sugar pill.
So for the time being 5 mg of cialis or 50 mg Viagra appear to be safe for men who can afford to take these pills everyday for 6 months. There are no data on women on take Viagra but if men have no problems, then I guess women should also be fine.
There was recent concern that use of drugs like Viagra could lead to impairment of vision or decreased vision at night. Some individuals also complained of blue vision. A recent study revealed that both drugs are safe and do not cause a higher vision loss compared to people who do not take Viagra. A well-controlled study did follow 244 men who took cialis or Viagra daily for 6 months (lucky guys had free Viagra because of the study). The study carefully analyzed vision and found no difference between those who took the drugs and those who took a sugar pill.
So for the time being 5 mg of cialis or 50 mg Viagra appear to be safe for men who can afford to take these pills everyday for 6 months. There are no data on women on take Viagra but if men have no problems, then I guess women should also be fine.
Monday, April 27, 2009
Epiduo Gel: promising drug for Acne part 2
The incidence of side effects with Epiduo gel was minimal and only 2% of individual had to discontinue the medication. The study revealed that Epiduo was well tolerated. The only side effects were minor skin redness and irritation.
Epiduo is very easy to use. A thin film should be applied on face, back, or upper arms after showering. If redness or skin irritation occurs, the drug should be discontinued for a few days.
Epiduo should not be used on skin that has been cut; sun burnt or if there is an infection. The gel should be avoided around eyes, nose, mouth and mucus membranes. After application of Epiduo, one should wear a sunscreen and avoid intense sunlight.
Final point: Epiduo does look to be a promising drug for acne. The drug is readily available but is somewhat expensive. The 45 g gel requires a prescription and costs about $50-$60.
For those individuals who have no more money to spend but already have topical accutane, perhaps they many want to combine it with benzyl peroxide for the best results. Benzyl peroxide is readily available without a prescription and is relatively cheap
Epiduo is very easy to use. A thin film should be applied on face, back, or upper arms after showering. If redness or skin irritation occurs, the drug should be discontinued for a few days.
Epiduo should not be used on skin that has been cut; sun burnt or if there is an infection. The gel should be avoided around eyes, nose, mouth and mucus membranes. After application of Epiduo, one should wear a sunscreen and avoid intense sunlight.
Final point: Epiduo does look to be a promising drug for acne. The drug is readily available but is somewhat expensive. The 45 g gel requires a prescription and costs about $50-$60.
For those individuals who have no more money to spend but already have topical accutane, perhaps they many want to combine it with benzyl peroxide for the best results. Benzyl peroxide is readily available without a prescription and is relatively cheap
Epiduo Gel: promising drug for Acne
Recently, FDA approved release of Epiduo, a gel for the treatment of acne vulgaris. The treatment of acne has never been satisfactory; many drugs have come and gone. Of all the drugs for acne, Retinoids have had the best success rate. Now we have a new product to help fight acne.
Epiduo is formulated with adapalene (0.1%) and benzyl peroxide (2.5 %,). Epiduo Gel is a relatively novel topical acne treatment that has been shown to be very effective for the treatment of inflammatory acne. Adapalene is a chemical that acts like a retinoid (Vitamin A). When combined with benzyl peroxide, the formulation can prevent infection, peel off old skin, and stimulate synthesis of fresh, younger, looking skin.
At present, there is no topical agent that is effective for acne. Epiduo gel is supposed to be applied once a day. This combination of a retinoid, adapalene, and benzyl peroxide, is claimed to be unique and very effective for certain types of acne.
The manufacturers of this product claim that this combination is very effective for mild and moderate inflamed acne. One study revealed that within the first week, nearly 18% of individuals had complete eradication of acne. By the end of 12 weeks, there was a 50 percent reduction in acne lesions. Further, this combination worked faster and without side effects.
Epiduo is formulated with adapalene (0.1%) and benzyl peroxide (2.5 %,). Epiduo Gel is a relatively novel topical acne treatment that has been shown to be very effective for the treatment of inflammatory acne. Adapalene is a chemical that acts like a retinoid (Vitamin A). When combined with benzyl peroxide, the formulation can prevent infection, peel off old skin, and stimulate synthesis of fresh, younger, looking skin.
At present, there is no topical agent that is effective for acne. Epiduo gel is supposed to be applied once a day. This combination of a retinoid, adapalene, and benzyl peroxide, is claimed to be unique and very effective for certain types of acne.
The manufacturers of this product claim that this combination is very effective for mild and moderate inflamed acne. One study revealed that within the first week, nearly 18% of individuals had complete eradication of acne. By the end of 12 weeks, there was a 50 percent reduction in acne lesions. Further, this combination worked faster and without side effects.
Friday, April 24, 2009
A look at weight loss drugs part 2
To fight the battle of bulge, physicians have only a few drugs to choose from. Some of these drugs are only recommended for short-term use because their long-term side effects remain unknown. Many weight loss experts claims that obese individuals can benefit from weight loss drugs. It is estimated that at least 25% of individuals who are obese may benefit from drug therapy.
The majority of weight loss drugs are derivatives or related to the central nervous stimulant- amphetamine. In the 60s and 70s, it was observed that individuals who took amphetamine and cocaine developed loss of appetite and weight loss. Soon the pharmaceutical companies developed analogues of drugs resembling amphetamine. In the 60s, little was know about addiction and physical dependence. Further, lawyers were not into malpractice at that time and thus, these drugs were used freely. Well, things soon began to change and by the 80s and 90s; lawyers knew there was money to be made in medicine and use of weight drugs declined in the 90s. Today, many lawyers know more about medical practice than physicians.
Besides amphetamine like drugs, other drugs that have been used for weight loss are diuretics and thyroid hormone. Both these drugs are not medically indicated for weight loss, but many patients self prescribe these drug for such use. With better understanding of obesity in the 1980s, different weight loss drugs were manufactured. Drugs like fen-phen helped individuals reduce weight loss, but the drug was associated with serious cardiac side effects and its use has been banned universally.
Since then, two new drugs with different mechanisms of action have been approved for use by the FDA. Sibutramine (Meridia) is a serotonin-norepinephrine reuptake inhibitor acts on the appetite center in the brain, and Orlistat (Xenical) is a pancreatic lipase inhibitor and inhibits the absorption of fat from the abdomen. However, these drugs do have side effects and their long term complications remain unknown. At present we have a huge gap in our armamentarium to treat obesity.
The majority of weight loss drugs are derivatives or related to the central nervous stimulant- amphetamine. In the 60s and 70s, it was observed that individuals who took amphetamine and cocaine developed loss of appetite and weight loss. Soon the pharmaceutical companies developed analogues of drugs resembling amphetamine. In the 60s, little was know about addiction and physical dependence. Further, lawyers were not into malpractice at that time and thus, these drugs were used freely. Well, things soon began to change and by the 80s and 90s; lawyers knew there was money to be made in medicine and use of weight drugs declined in the 90s. Today, many lawyers know more about medical practice than physicians.
Besides amphetamine like drugs, other drugs that have been used for weight loss are diuretics and thyroid hormone. Both these drugs are not medically indicated for weight loss, but many patients self prescribe these drug for such use. With better understanding of obesity in the 1980s, different weight loss drugs were manufactured. Drugs like fen-phen helped individuals reduce weight loss, but the drug was associated with serious cardiac side effects and its use has been banned universally.
Since then, two new drugs with different mechanisms of action have been approved for use by the FDA. Sibutramine (Meridia) is a serotonin-norepinephrine reuptake inhibitor acts on the appetite center in the brain, and Orlistat (Xenical) is a pancreatic lipase inhibitor and inhibits the absorption of fat from the abdomen. However, these drugs do have side effects and their long term complications remain unknown. At present we have a huge gap in our armamentarium to treat obesity.
A look at weight loss drugs
There is no doubt that certain drugs can help individuals lose weight. However, all consumers should understand that drugs are not the magic bullet for weight loss. One must compliment drugs with life style changes for the best response.
The major problem with our society is that everyone wants an easy way to weight loss- popping a pill without making any effort. The problem with weight gain is not in the stomach but with the psyche. One needs a treatment to motivate people to start walking.
All over the globe, waistlines are increasing and obesity is endemic. The pharmaceutical companies are trying desperately hard to come up with a decent drug because they know there is money to be made. However, since the fen fen fiasco, the resulting litigations have tempered the urge of all pharmaceutical companies to quickly release another product.
There are many drugs on the market that can help individuals lose weight, but the point is that almost each and every one of these drugs has disturbing side effects. Some drugs are addictive and yet others can even damage the body. The other reason why weight loss drugs are not prescribed frequently is because physicians have become targets of both patients and FDA. Whenever a complication results, physicians are the first to be sued. Second, the FDA tends to believe that physicians are prescribing way too many drugs and contribute to the burgeoning problems of addiction in society (true when it comes to pain pill prescriptions).
The major problem with our society is that everyone wants an easy way to weight loss- popping a pill without making any effort. The problem with weight gain is not in the stomach but with the psyche. One needs a treatment to motivate people to start walking.
All over the globe, waistlines are increasing and obesity is endemic. The pharmaceutical companies are trying desperately hard to come up with a decent drug because they know there is money to be made. However, since the fen fen fiasco, the resulting litigations have tempered the urge of all pharmaceutical companies to quickly release another product.
There are many drugs on the market that can help individuals lose weight, but the point is that almost each and every one of these drugs has disturbing side effects. Some drugs are addictive and yet others can even damage the body. The other reason why weight loss drugs are not prescribed frequently is because physicians have become targets of both patients and FDA. Whenever a complication results, physicians are the first to be sued. Second, the FDA tends to believe that physicians are prescribing way too many drugs and contribute to the burgeoning problems of addiction in society (true when it comes to pain pill prescriptions).
Monday, April 20, 2009
Zyatrim: Another junk weight loss pill? part 2
Zyatrim is heavily marketed as a revolutionary weight loss pill available without a prescription. It is claimed to be thermogenic, meaning it can dissolve fat and generate calories. The manufacturers use fancy names like apoptosis meaning that it induces the fat cells to die prematurely and Voila, you become thin in a few hours. The pill is supposed to be taken twice a day. One takes Zyatrim until the desired weight is reached.
The website claims that the weight loss induced by Zyatrim is permanent because the fat cells are destroyed for ever. And what is astonishing is that it starts to work within one hour.
What is even more incredible is that this so called reputable company also has a whole page where it trashes every other weight loss pill. Not a very professional way to conduct a business. If Zyatrim worked, why not let it effectiveness do the talking? And just to add some more information- Zyatrim is not approved by the FDA.
The ingredients listed in Zyatrim are extracts of Acacia Rigidula. Acacia Rigidula is a tree which grows in Central America, including Mexico. For decades it was observed that this plant was eaten by the wild goats that never got fat. Other ingredients that have been extracted from this tree and included in the formulation include methylsynephrine, phenylethylamine, Cassis nomane, theobromine, Yohimbine and ECGC. This combination is said to reverse the weight gain.
What does Zyatrim cost?
A month’s supply of Zyatrim is only $50, of course the more you buy the bigger the discounts (if a pill worked that great, would any company sell it for less, especially a weight loss pill?).
Now to the facts. There is ZERO evidence that Zyatrim works. There are no clinical trials nor is there a single piece of scientific information which can back up claims made by the manufacturer of Zyatrim. In fact, all over cyberspace there are many individuals whose testimony counters what the manufacturers says. The refund policy is dubious and money is never refunded. The ingredients listed are nothing special. These ingredients have been around for centuries and asides from working like a caffeinated product do nothing else.
Does anyone really believe that the FDA would allow a weight loss product to be sold online without a prescription if the above listed ingredients listed were present? Despite reports that extracts of this tree contain potent alkaloids and other chemicals, these results have never been verified in a scientific laboratory and are considered to be a hoax. There is no mention of Zyatrim in any scientific research study.
The economy is difficult today and in such times there are always charlatans who prey on other people’s hopes and dreams. Zyatrim is not the pill you should take to lose weight. The plant, Acacia Rigidula., from which Zyatrim is derived, is best left for the wild goats in Mexico. In other words- it is CRAP.
If you want to lose weight, start walking more, eat less and avoid dubious products like Zyatrim. This proven method is cheaper, works and will save you money- try it.
The website claims that the weight loss induced by Zyatrim is permanent because the fat cells are destroyed for ever. And what is astonishing is that it starts to work within one hour.
What is even more incredible is that this so called reputable company also has a whole page where it trashes every other weight loss pill. Not a very professional way to conduct a business. If Zyatrim worked, why not let it effectiveness do the talking? And just to add some more information- Zyatrim is not approved by the FDA.
The ingredients listed in Zyatrim are extracts of Acacia Rigidula. Acacia Rigidula is a tree which grows in Central America, including Mexico. For decades it was observed that this plant was eaten by the wild goats that never got fat. Other ingredients that have been extracted from this tree and included in the formulation include methylsynephrine, phenylethylamine, Cassis nomane, theobromine, Yohimbine and ECGC. This combination is said to reverse the weight gain.
What does Zyatrim cost?
A month’s supply of Zyatrim is only $50, of course the more you buy the bigger the discounts (if a pill worked that great, would any company sell it for less, especially a weight loss pill?).
Now to the facts. There is ZERO evidence that Zyatrim works. There are no clinical trials nor is there a single piece of scientific information which can back up claims made by the manufacturer of Zyatrim. In fact, all over cyberspace there are many individuals whose testimony counters what the manufacturers says. The refund policy is dubious and money is never refunded. The ingredients listed are nothing special. These ingredients have been around for centuries and asides from working like a caffeinated product do nothing else.
Does anyone really believe that the FDA would allow a weight loss product to be sold online without a prescription if the above listed ingredients listed were present? Despite reports that extracts of this tree contain potent alkaloids and other chemicals, these results have never been verified in a scientific laboratory and are considered to be a hoax. There is no mention of Zyatrim in any scientific research study.
The economy is difficult today and in such times there are always charlatans who prey on other people’s hopes and dreams. Zyatrim is not the pill you should take to lose weight. The plant, Acacia Rigidula., from which Zyatrim is derived, is best left for the wild goats in Mexico. In other words- it is CRAP.
If you want to lose weight, start walking more, eat less and avoid dubious products like Zyatrim. This proven method is cheaper, works and will save you money- try it.
Zyatrim: Another junk weight loss pill?
Over the past few decades, many new weight loss pills have come and gone. Each week there is a different pill or herb for weight loss. The claims are astonishing- weight loss in a day, permanent weight loss, lose 100 pounds in 4 weeks, look great, feel great, your booty will be gone in a week, your bum will disappear in 2 weeks and so on. There are so many pills and herbs- the whole weight loss industry has gone crazy. For the consumer desperate for weight loss this can be confusing, irritating and expensive. Which pill to try next is an ongoing task.
First, just the facts. Weight loss pills have been around for more than 50 years and more pills hand herbs have been developed in the past decade than at any other time in history. Obesity is not only an American problem,- even in Africa, a continent which has always been caught up with famine and drought has the obesity bug. And in each and every country, there are pills, creams and lotions- all the ads are same. Our pills are the best and most effective.
So do any of these pills work?
Fact -if any pill has worked or is working to decrease obesity, then it is pure chance. In this entire universe it is difficult to find more than 5-10 people who have gone on to lose weight by using over the counter weight loss pills.
So now we come to Zyatrim.
First, just the facts. Weight loss pills have been around for more than 50 years and more pills hand herbs have been developed in the past decade than at any other time in history. Obesity is not only an American problem,- even in Africa, a continent which has always been caught up with famine and drought has the obesity bug. And in each and every country, there are pills, creams and lotions- all the ads are same. Our pills are the best and most effective.
So do any of these pills work?
Fact -if any pill has worked or is working to decrease obesity, then it is pure chance. In this entire universe it is difficult to find more than 5-10 people who have gone on to lose weight by using over the counter weight loss pills.
So now we come to Zyatrim.
Thursday, April 9, 2009
Sibutramine- safe weight loss drug Part 2
Who cannot take Sibutramine?
Sibutramine is not indicated for all individuals. Individuals who have mental health problems should refrain from taking this drug as it may make the symptoms worse. Those individual with a history of high blood pressure can take the drug but should be closely monitored. Because the drug has not been fully evaluated in pregnancy, females anticipating getting pregnant or those who are breast-feeding should avoid Sibutramine.
What complications can occur with Sibutramine?
Over the years, there have been a few rare cases of heart attacks and kidney failure, which have caused concern in the medical community and FDA. It is important to note that the number of individuals who developed the complications were very small. All short-term studies have shown the drug to be safe.
How much Sibutramine does one take?
Sibutramine is generally taken once a day- the starting dose is usually 10 mg and this can be increased slowly by 5 mg/week until one sees a reduction in appetite. Doses as high as 60mg have been studied without any major side effects.
To be safe, it is important for all individuals taking sibutramine to be closely followed by a health care professional. Further, it is important not to take the drug for more than 2 months. If it has not worked by the end of 2 months, it is not likely to work if taken any longer. Taking it longer only increases the chance of complications.
Does Sibutramine work in everyone?
No, at best it works in about 60% of individuals. For those who intend to use Sibutramine, it is highly recommended that one also change the lifestyle, eat less, and enter an exercise program. These changes can help one sustain the weight loss achieved with Sibutramine.
Sibutramine is not indicated for all individuals. Individuals who have mental health problems should refrain from taking this drug as it may make the symptoms worse. Those individual with a history of high blood pressure can take the drug but should be closely monitored. Because the drug has not been fully evaluated in pregnancy, females anticipating getting pregnant or those who are breast-feeding should avoid Sibutramine.
What complications can occur with Sibutramine?
Over the years, there have been a few rare cases of heart attacks and kidney failure, which have caused concern in the medical community and FDA. It is important to note that the number of individuals who developed the complications were very small. All short-term studies have shown the drug to be safe.
How much Sibutramine does one take?
Sibutramine is generally taken once a day- the starting dose is usually 10 mg and this can be increased slowly by 5 mg/week until one sees a reduction in appetite. Doses as high as 60mg have been studied without any major side effects.
To be safe, it is important for all individuals taking sibutramine to be closely followed by a health care professional. Further, it is important not to take the drug for more than 2 months. If it has not worked by the end of 2 months, it is not likely to work if taken any longer. Taking it longer only increases the chance of complications.
Does Sibutramine work in everyone?
No, at best it works in about 60% of individuals. For those who intend to use Sibutramine, it is highly recommended that one also change the lifestyle, eat less, and enter an exercise program. These changes can help one sustain the weight loss achieved with Sibutramine.
Sibutramine- safe weight loss drug
Sibutramine also known as Meridia is a relatively drug to help individuals lose weight. The drug has been available in Europe for many years but has only been available in the USA for a few years.
How does it work?
Sibutramine acts by inhibiting the desire to eat. The drug enters the brain and inhibits the appetite center
How is the drug administered?
Sibutramine is available as a pill and taken daily for 1-2 months to have the desired results.
Does Sibutramine work?
Most definitely, it works and does reduce weight. However, the problem is that the drug does have a few undesirable side effects
How long can one take Sibutramine?
The drug is approved by the FDA for short-term use only and is generally safe if taken for that time period (usually less than 8 weeks). A number of large-scale clinical studies have concluded that short-term use of Sibutramine is safe. It is only when the drug is taken for many months that the side effects become prevalent.
How much weight can one lose on Sibutramine?
Most people who have taken sibutramine notice a weight loss of anywhere from 10-12 pounds over 6-8 weeks.
What are the side effects of Sibutramine?
The most common side effects of the drug include the following:
- dry mouth
- nausea
- metallic or acid taste in the mouth
- abdominal cramps, bloating,
- stomach pain
- headaches
- joint pains
- facial flushing
- increased blood pressure
- chest palpitations
- mood changes like depression,, anxiety
- chest pain
- shortness of breath
Not everyone develops these side effects. European studies indicate that about one in a hundred individuals may develop one or more of the above side effects. All the side effects disappear when the drug is discontinued
How does it work?
Sibutramine acts by inhibiting the desire to eat. The drug enters the brain and inhibits the appetite center
How is the drug administered?
Sibutramine is available as a pill and taken daily for 1-2 months to have the desired results.
Does Sibutramine work?
Most definitely, it works and does reduce weight. However, the problem is that the drug does have a few undesirable side effects
How long can one take Sibutramine?
The drug is approved by the FDA for short-term use only and is generally safe if taken for that time period (usually less than 8 weeks). A number of large-scale clinical studies have concluded that short-term use of Sibutramine is safe. It is only when the drug is taken for many months that the side effects become prevalent.
How much weight can one lose on Sibutramine?
Most people who have taken sibutramine notice a weight loss of anywhere from 10-12 pounds over 6-8 weeks.
What are the side effects of Sibutramine?
The most common side effects of the drug include the following:
- dry mouth
- nausea
- metallic or acid taste in the mouth
- abdominal cramps, bloating,
- stomach pain
- headaches
- joint pains
- facial flushing
- increased blood pressure
- chest palpitations
- mood changes like depression,, anxiety
- chest pain
- shortness of breath
Not everyone develops these side effects. European studies indicate that about one in a hundred individuals may develop one or more of the above side effects. All the side effects disappear when the drug is discontinued
Monday, April 6, 2009
Xenical (AKA Orlistat) – a good weight loss pill? Part 2
What is alli?
Alli is a brand name of Orlistat and available without a prescription. Alli is only half the prescription strength of Orlistat. Two pills of alli equal one Orlistat pill
How effective is Orlistat?
Well, it is an effective drug for weight loss. The weight loss usually occurs gradually over a period of 2-3 months.
Does Orlistat work in everyone?
No, for some unknown reason it only works in less than 40% of individuals. Asians, Orientals and Africans appear to have a genetic difference in the enzyme, lipase. The enzyme is not effectively inhibited by Orlistat in this patient population.
What else can one do to lose weight?
Orlistat is not the magic pill for weight loss and one also needs to eat less, and enter an exercise program
How much weight can one lose with Orlistat?
Most people claim that they lose 10-15 pounds over 4-6 months. Long term use does not seem to increase this weight loss
What is the dose of Orlistat?
The dose of prescription Orlistat is 120 mg and is supposed to be taken I hr before each meal.
What else should I know about Orlistat?
Because a few vitamins need fat to be absorbed in the blood stream, Orlistat use can prevent absorption of vitamins A, D, E, and K. Thus, one has to take supplements of these enzymes. Never take the vitamins supplements at the same time as Orlistat- they will simply be eliminated in the poop.
What are side effects of Orlistat?
Orlistat is a safe drug but has unpleasant side effects. It is because of the side effects that most people cannot take Orlistat for long periods. Passage of fat into the bowels lead to a lot of gas, abdominal cramps, frothy and oily stool. Plus, the oily stools often leak out of the anus and soil the under pants.
These side effects are less when the drug is not taken every day. The side effects do resolve when the pill is stopped. Some people wear diapers during this time to avoid repeated soilage of their underwear
What is cost of the Orlistat?
Orlistat is fairly expensive. Each pill can cost anywhere from $2-$3. One needs to take each pill 3 times a day. This can amount to about $200-$300 a month. This may sound a lot but bariatric surgery can cost $15,000-$25,000.
Final advice
Do not take Orlistat which requires a prescription and is expensive.. If you want to lose weight, take alli which is the same pill, costs much less and one does not need a prescription. Alli is available at half the strength and works just as well
Alli is a brand name of Orlistat and available without a prescription. Alli is only half the prescription strength of Orlistat. Two pills of alli equal one Orlistat pill
How effective is Orlistat?
Well, it is an effective drug for weight loss. The weight loss usually occurs gradually over a period of 2-3 months.
Does Orlistat work in everyone?
No, for some unknown reason it only works in less than 40% of individuals. Asians, Orientals and Africans appear to have a genetic difference in the enzyme, lipase. The enzyme is not effectively inhibited by Orlistat in this patient population.
What else can one do to lose weight?
Orlistat is not the magic pill for weight loss and one also needs to eat less, and enter an exercise program
How much weight can one lose with Orlistat?
Most people claim that they lose 10-15 pounds over 4-6 months. Long term use does not seem to increase this weight loss
What is the dose of Orlistat?
The dose of prescription Orlistat is 120 mg and is supposed to be taken I hr before each meal.
What else should I know about Orlistat?
Because a few vitamins need fat to be absorbed in the blood stream, Orlistat use can prevent absorption of vitamins A, D, E, and K. Thus, one has to take supplements of these enzymes. Never take the vitamins supplements at the same time as Orlistat- they will simply be eliminated in the poop.
What are side effects of Orlistat?
Orlistat is a safe drug but has unpleasant side effects. It is because of the side effects that most people cannot take Orlistat for long periods. Passage of fat into the bowels lead to a lot of gas, abdominal cramps, frothy and oily stool. Plus, the oily stools often leak out of the anus and soil the under pants.
These side effects are less when the drug is not taken every day. The side effects do resolve when the pill is stopped. Some people wear diapers during this time to avoid repeated soilage of their underwear
What is cost of the Orlistat?
Orlistat is fairly expensive. Each pill can cost anywhere from $2-$3. One needs to take each pill 3 times a day. This can amount to about $200-$300 a month. This may sound a lot but bariatric surgery can cost $15,000-$25,000.
Final advice
Do not take Orlistat which requires a prescription and is expensive.. If you want to lose weight, take alli which is the same pill, costs much less and one does not need a prescription. Alli is available at half the strength and works just as well
Xenical (AKA Orlistat) – a good weight loss pill?
What is Xenical?
In the last 40 years many weight loss pills have been developed. The majority have been derivatives of the addictive drug, amphetamine. While these drugs have been effective, they also have had serious side effects including physical dependence. Now there is a new weight loss pill known as Orlistat (Xenical).
How is it administered?
Xenical is available as a prescription pill and can help one reduce weight.
How does it work?
Orlistat works by preventing absorption of fat from the intestine. For a normal person, before fat can be absorbed into the blood stream, it has to be broken down into smaller fragments by an enzyme in the intestine. This enzyme, lipase, is blocked by Orlistat. Once the enzyme is blocked, any ingested fat is simply excreted into the feces. The maximum inhibition of the enzyme by Orlistat is not 100 percent but ranges anywhere from 50%-80%
What happens to the fat one eats?
Because the fat is no longer broken down, it is excreted and appears in the stools. The stools appear frothy, bulky and have a distinct smell. The stools also appear greasy and can fill up the entire toilet because of the froth.
When does one take the pill?
Orlistat is best taken at least an hour before a fatty meal. If you are not going to eat fat, there is no point in taking the pill
In the last 40 years many weight loss pills have been developed. The majority have been derivatives of the addictive drug, amphetamine. While these drugs have been effective, they also have had serious side effects including physical dependence. Now there is a new weight loss pill known as Orlistat (Xenical).
How is it administered?
Xenical is available as a prescription pill and can help one reduce weight.
How does it work?
Orlistat works by preventing absorption of fat from the intestine. For a normal person, before fat can be absorbed into the blood stream, it has to be broken down into smaller fragments by an enzyme in the intestine. This enzyme, lipase, is blocked by Orlistat. Once the enzyme is blocked, any ingested fat is simply excreted into the feces. The maximum inhibition of the enzyme by Orlistat is not 100 percent but ranges anywhere from 50%-80%
What happens to the fat one eats?
Because the fat is no longer broken down, it is excreted and appears in the stools. The stools appear frothy, bulky and have a distinct smell. The stools also appear greasy and can fill up the entire toilet because of the froth.
When does one take the pill?
Orlistat is best taken at least an hour before a fatty meal. If you are not going to eat fat, there is no point in taking the pill
Sunday, April 5, 2009
Is there a drug(s) to halt dementia in patients with Alzheimer's?
In the last decade a number of medications have been developed to reverse/halt the effects of dementia. One of the most common disorders associated with dementia world wide is Alzheimer’s. This awful disease generally starts around the age 70 and progresses relentlessly. Now drug companies are marketing drugs to help halt or reverse the dementia . The first such drug used to reverse dementia was Aricept. Since then, a variety of other nootropic drugs have been developed including donepezil, galantamine, and rivastigmine. A number of clinical studies have been done comparing these drugs to placebo in patients with Alzheimer’s.
In all the studies, only the mildest cases of Alzheimer’s dementia was improved with these drugs. Further, there was no difference between the drugs. The most clear finding from these trials was that these drugs had significant side effects and close to 30-50 percent of patients had to discontinue the drugs.
At the moment, these nootropic drugs have not been the panacea for treatment of dementia. These drugs do not work in all types of dementia except Alzheimer’s. And even when the drugs work, only the mild cases of Alzheimer’s disease improves. Finally, these drugs are fairly expensive and not everyone responds to them. Less than 5 percent of patient show any significant improvement.
So what is the consumer supposed to do? Most experts do not recommend these drugs because of the profound side effects which makes the individual worse than he/she previously was. Further these medications have to be taken every day and do not cure Alzheimer’s disease. The beneficial effects of these drugs are not long lasting and stop the moment the drug is discontinued.
The decision of whether to start drug therapy to reverse or halt dementia is personal and requires some clinical judgment. Unfortunately so far no drug has made any great impact on the disease. As of today, loving and supportive care of your family member is still better than any drug therapy for Alzheimer’s disease
In all the studies, only the mildest cases of Alzheimer’s dementia was improved with these drugs. Further, there was no difference between the drugs. The most clear finding from these trials was that these drugs had significant side effects and close to 30-50 percent of patients had to discontinue the drugs.
At the moment, these nootropic drugs have not been the panacea for treatment of dementia. These drugs do not work in all types of dementia except Alzheimer’s. And even when the drugs work, only the mild cases of Alzheimer’s disease improves. Finally, these drugs are fairly expensive and not everyone responds to them. Less than 5 percent of patient show any significant improvement.
So what is the consumer supposed to do? Most experts do not recommend these drugs because of the profound side effects which makes the individual worse than he/she previously was. Further these medications have to be taken every day and do not cure Alzheimer’s disease. The beneficial effects of these drugs are not long lasting and stop the moment the drug is discontinued.
The decision of whether to start drug therapy to reverse or halt dementia is personal and requires some clinical judgment. Unfortunately so far no drug has made any great impact on the disease. As of today, loving and supportive care of your family member is still better than any drug therapy for Alzheimer’s disease
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