Gelnique formulation is a colorless, fragrance free solution that contains some alcohol. It dries up quickly once applied on the skin. The dose of Gelnique is 1 g (1 ml) applied once a day. The gel may be applied on the thighs, abdomen, upper arms, or shoulder. Once Gelnique is applied on skin, there is constant absorption over the next 24 hours, resulting in a constant effect with minimal side effects.
Further studies have shown that absorption of Gelnique from the skin is not affected by showering 1 hour later or by applying sunscreen 30 minutes before or after applying the drug.
Gelnique is not recommended for use in individuals who have or at risk of developing
- urinary retention
- men with prostatic hypertrophy
- individuals with gastroparesis
- individuals with uncontrolled narrow angle glaucoma
- individual with allergy to the agent
Other medical disorders where the oxybutynin should be used with caution is in individuals with impairment of liver, kidney, muscle paralysis, ulcerative colitis, constipation, or reflux.
Because the gel can be transferred from human to human by vigorous skin to skin contact at the application site, washing of hands and avoidance of close contact with children is recommended for the first few hours. Since the drug is made in an alcoholic solution, one should avoid smoking, or close contact with heating or fire appliance until the gel is completely dry.
No comments:
Post a Comment