How will I know if Plan B One-Step worked?
Women who take the pill will have their next menstrual period at the expected time or within 7 days of the expected time. If the menstrual period is delayed beyond by more than 7 days, than the pill has not worked and you may be pregnant. In such a case, you should get a pregnancy test.
How often can I use Plan B One-Step?
Plan B One-Step is only meant for emergency use. One should use common sense and learn about other methods of contraception rather than rely on an emergency pill.
Who should not use plan B one Step?
- Those who are pregnant (because it will not work)
- If you are allergic to progestins or any of the
ingredients in Plan B One-Step
- Those seeking regular birth control
Protect yourself in more ways than one. Plan B One-Step is an emergency contraceptive pill that helps prevent pregnancy after unprotected sex or when your birth control fails or is not used correctly.
Remember, Plan B One-Step is only for emergency pregnancy prevention. There are many other pills and products that work for regular birth control. Talk to your health professional if you want to know about contraception and what may work for you.
The cost of Plan B one step ranges from $35-$50
Thursday, December 31, 2009
Emergency pill to prevent pregnancy: Part 2
Does plan B one step completely prevent pregnancy?
Once the pill is taken pregnancy is usually averted but 2 out of 100 women may develop an ectopic pregnancy. Any female takes Plan B One step who 4-6 weeks later develops lower abdominal pain or becomes pregnant should see a physician to determine the status of the pregnancy.
Does Plan B one step work if one is pregnant?
Once pregnancy has occurred plan B step one does not work. Moreover Plan B one step does not protect against any sexually transmitted infections.
Does one need to see a physician before taking the pill?
Females who have had unprotected sex and want to avert a pregnancy can take the pill without a physical exam by a physician. However, if after the pill the period is delayed by more than 1 week, one should seek medical attention. Plan B one step should not be used as a means of routine contraception.
How does the pill work?
The pill is believed to act by preventing ovulation or fertilization of sperm and ova.
Does plan B one step work all the time?
Unfortunately there is no such thing as 100 percent with any pill. Studies show that more than 95% of women who took Plan b one step did not get pregnant
Once the pill is taken pregnancy is usually averted but 2 out of 100 women may develop an ectopic pregnancy. Any female takes Plan B One step who 4-6 weeks later develops lower abdominal pain or becomes pregnant should see a physician to determine the status of the pregnancy.
Does Plan B one step work if one is pregnant?
Once pregnancy has occurred plan B step one does not work. Moreover Plan B one step does not protect against any sexually transmitted infections.
Does one need to see a physician before taking the pill?
Females who have had unprotected sex and want to avert a pregnancy can take the pill without a physical exam by a physician. However, if after the pill the period is delayed by more than 1 week, one should seek medical attention. Plan B one step should not be used as a means of routine contraception.
How does the pill work?
The pill is believed to act by preventing ovulation or fertilization of sperm and ova.
Does plan B one step work all the time?
Unfortunately there is no such thing as 100 percent with any pill. Studies show that more than 95% of women who took Plan b one step did not get pregnant
Emergency pill to prevent pregnancy: Part 1
Women who need an emergency contraceptive pill to protect against pregnancy should take Plan B One step. Plan B One Step is a progestin only contraceptive pill which can prevent pregnancy following unprotected sex or when there is a failure of the condom. To ensure that the pill works it must be taken as soon as possible at least within the first 48-72 hours. After 3 days, the pill will not work. The two pills have two be taken 12 hours apart.
With recent FDA approval, both Plan B One-Step and Plan B will be available without a prescription to women 17 years of age and older. They will both be available for women younger than 17 years of age only by prescription.
What are side effects of Plan B One step?
If vomiting occurs within 2 hours of taking the pill, one should repeat the dose. While the drug is deemed safe, it does have a few side effects like:
Heavy menstrual bleeding
Nausea and vomiting
Lower abdominal cramps
Fatigue
Dizziness
Breast soreness and nipple tenderness
Delayed menses
With recent FDA approval, both Plan B One-Step and Plan B will be available without a prescription to women 17 years of age and older. They will both be available for women younger than 17 years of age only by prescription.
What are side effects of Plan B One step?
If vomiting occurs within 2 hours of taking the pill, one should repeat the dose. While the drug is deemed safe, it does have a few side effects like:
Heavy menstrual bleeding
Nausea and vomiting
Lower abdominal cramps
Fatigue
Dizziness
Breast soreness and nipple tenderness
Delayed menses
Sunday, November 22, 2009
BISACODYL SUPPOSITORY 10 MG 100 PER BOTTLE
Bisacodyl is classified as a suppository and widely used to treat constipation and colonic evacuation prior to any type of surgical procedure or examination. It is also sold as Alophen; Bisac-Evac™; Bisacodyl Uniserts; Correctol Tablets; Femilax™; Fleet Bisacodyl Enema; Fleet Stimulant Laxative; Gentlax; Modane Tablets and Veracolate. Bisacodyl is available over the counter and does not require a prescription.
Bisacodyl works by increasing peristalsis of the bowel walls and leads to increased motility. It also alters the water and electrolyte secretion producing net intestinal fluid loss and relaxation. Once the suppository is inserted, it works within 5-10 minutes. It is best to take the suppository as needed first thing in the morning. The recommended dose is 10 mg, and one should not exceed more than 3 doses a day.
Bisacodyl is available as an enema (10 mg solution) or as a suppository tablet. The suppository has few mild side effects which include mild abdominal cramps, nausea, vomiting or rectal irritation. These side effects usually subside in a few minutes. Bisacodyl is only meant to be used in children over the age of 6 and adults.
Individuals who have hypersensitivity to Bisacodyl or any component of the formula should avoid this product.
Bisacodyl works by increasing peristalsis of the bowel walls and leads to increased motility. It also alters the water and electrolyte secretion producing net intestinal fluid loss and relaxation. Once the suppository is inserted, it works within 5-10 minutes. It is best to take the suppository as needed first thing in the morning. The recommended dose is 10 mg, and one should not exceed more than 3 doses a day.
Bisacodyl is available as an enema (10 mg solution) or as a suppository tablet. The suppository has few mild side effects which include mild abdominal cramps, nausea, vomiting or rectal irritation. These side effects usually subside in a few minutes. Bisacodyl is only meant to be used in children over the age of 6 and adults.
Individuals who have hypersensitivity to Bisacodyl or any component of the formula should avoid this product.
Calmoseptine an excellent multipurpose skin barrier cream
One of the best multipurpose skin barrier creams is Calmoseptine. Consisting of topical zinc oxide, this multipurpose ointment is easy to apply, provides immediate symptom relief and is relatively cheap.
Calmoseptine can be used to treat a number of skin disorders including:
Dry skin
Itchy skin
Chapped skin
Diaper rash
Minor burns
Abrasions
Bee stings
Treat skin around ileostomy or colostomy
Diaper Rash
Leakage around feeding tubes or other catheters
Rash around genitals resulting from bladder or bowel incontinence
Calmoseptine is also combined with various creams to relieve itching, pain and burning that is common with hemorrhoids. The consumer should understand that Calmoseptine does not function like an antibiotic but is best considered a skin barrier cream. In hospitals and homes, it can be used to treat skin dryness and rashes from any number of causes.
Calmoseptine is easy to apply and does not have to rubbed or massaged into the skin. In general, Calmoseptine is best applied as a light film and should be applied twice a day. Prior to application, the skin area should be cleansed with warm water and padded dry. Today, Calmoseptine suppositories are also available for use in people who have hemorrhoids or rectal discomfort from anal fistulas.
Calmoseptine should be avoided around the eyes, nose or mouth. If the ointment does get in the eye, thoroughly wash the eye with water for 10-15 minutes. Calmoseptine should not be applied on completely raw ulcerated skin, open wounds or profusely bleeding wounds.
Calmoseptine can be used to treat a number of skin disorders including:
Dry skin
Itchy skin
Chapped skin
Diaper rash
Minor burns
Abrasions
Bee stings
Treat skin around ileostomy or colostomy
Diaper Rash
Leakage around feeding tubes or other catheters
Rash around genitals resulting from bladder or bowel incontinence
Calmoseptine is also combined with various creams to relieve itching, pain and burning that is common with hemorrhoids. The consumer should understand that Calmoseptine does not function like an antibiotic but is best considered a skin barrier cream. In hospitals and homes, it can be used to treat skin dryness and rashes from any number of causes.
Calmoseptine is easy to apply and does not have to rubbed or massaged into the skin. In general, Calmoseptine is best applied as a light film and should be applied twice a day. Prior to application, the skin area should be cleansed with warm water and padded dry. Today, Calmoseptine suppositories are also available for use in people who have hemorrhoids or rectal discomfort from anal fistulas.
Calmoseptine should be avoided around the eyes, nose or mouth. If the ointment does get in the eye, thoroughly wash the eye with water for 10-15 minutes. Calmoseptine should not be applied on completely raw ulcerated skin, open wounds or profusely bleeding wounds.
Coban 2 Layer Compression System
There are many types of compression dressings and one of the most widely used is the coban 2 layer compression system. This dressing can be used for both open and closed wounds. In most cases, coban 2 later compression dressing work well in the extremities and over joints.
The first layer provides comfort and relieves itching and redness. When vigilantly applied, the dressing immediately delivers comfort and effective compression. It consists of two latex-free roll bandages. The internal comfort layer is a lamination of polyurethane foam and an adhesive bandage. The outer compression layer is an adhesive bandage, intended to provide constant, compression at levels which are known to be effective for the treatment of leg swelling and venous ulcers.
Once the 2 layers of the dressing have been applied, the two layers merge and become on solid bandage that does not easily slip during daily walking
The coban compression system may be worn for 5-7 days at a time. The dressing can also be used to relieve leg swelling from heart failure and related disorders. It is best not to use the coban dressing as a wound cover because such it is not frequently changed.
Coban compression dressings can be bought from any medical supplier. The dressings are available as both unstretchable and stretchable bandages.
The first layer provides comfort and relieves itching and redness. When vigilantly applied, the dressing immediately delivers comfort and effective compression. It consists of two latex-free roll bandages. The internal comfort layer is a lamination of polyurethane foam and an adhesive bandage. The outer compression layer is an adhesive bandage, intended to provide constant, compression at levels which are known to be effective for the treatment of leg swelling and venous ulcers.
Once the 2 layers of the dressing have been applied, the two layers merge and become on solid bandage that does not easily slip during daily walking
The coban compression system may be worn for 5-7 days at a time. The dressing can also be used to relieve leg swelling from heart failure and related disorders. It is best not to use the coban dressing as a wound cover because such it is not frequently changed.
Coban compression dressings can be bought from any medical supplier. The dressings are available as both unstretchable and stretchable bandages.
BISCADODYL TABS 5 MG
Bisacodyl is classified as a laxative and widely used to treat constipation and colonic evacuation prior to any type of surgical procedure or examination. It is also sold as Alophen; Bisac-Evac™; Bisacodyl Uniserts; Correctol Tablets; Femilax™; Fleet Bisacodyl Enema; Fleet Stimulant Laxative; Gentlax; Modane Tablets and Veracolate. Bisacodyl is available over the counter and does not require a prescription.
Bisacodyl works by increasing peristalsis of the bowel walls and leads to increased motility. It also alters the water and electrolyte secretion producing net intestinal fluid loss and relaxation. Once the tablet is taken with water, it works within 6-10 hours. It is best to take the tablet at night on an empty stomach. The tablet should not be crushed in the mouth but swallowed whole.
The recommended dose is 5-10 mg, and one should not exceed more than 3 doses a day. One should avoid taking Bisacodyl with dairy or milk products as the absorption can be delayed. The drugs has few mild side effects which include mild abdominal cramps, nausea, vomiting or rectal irritation. These side effects usually subside in a few minutes.
Bisacodyl is only meant to be used in children over the age of 6 and adults.
Individuals who have hypersensitivity to Bisacodyl or any component of the formula should avoid this product.
Bisacodyl works by increasing peristalsis of the bowel walls and leads to increased motility. It also alters the water and electrolyte secretion producing net intestinal fluid loss and relaxation. Once the tablet is taken with water, it works within 6-10 hours. It is best to take the tablet at night on an empty stomach. The tablet should not be crushed in the mouth but swallowed whole.
The recommended dose is 5-10 mg, and one should not exceed more than 3 doses a day. One should avoid taking Bisacodyl with dairy or milk products as the absorption can be delayed. The drugs has few mild side effects which include mild abdominal cramps, nausea, vomiting or rectal irritation. These side effects usually subside in a few minutes.
Bisacodyl is only meant to be used in children over the age of 6 and adults.
Individuals who have hypersensitivity to Bisacodyl or any component of the formula should avoid this product.
BISCADODYL TABS 5 MG
Bisacodyl is classified as a laxative and widely used to treat constipation and colonic evacuation prior to any type of surgical procedure or examination. It is also sold as Alophen; Bisac-Evac™; Bisacodyl Uniserts; Correctol Tablets; Femilax™; Fleet Bisacodyl Enema; Fleet Stimulant Laxative; Gentlax; Modane Tablets and Veracolate. Bisacodyl is available over the counter and does not require a prescription.
Bisacodyl works by increasing peristalsis of the bowel walls and leads to increased motility. It also alters the water and electrolyte secretion producing net intestinal fluid loss and relaxation. Once the tablet is taken with water, it works within 6-10 hours. It is best to take the tablet at night on an empty stomach.
The tablet should not be crushed in the mouth but swallowed whole. The recommended dose is 5-10 mg, and one should not exceed more than 3 doses a day. One should avoid taking Bisacodyl with dairy or milk products as the absorption can be delayed. The drug has few mild side effects which include mild abdominal cramps, nausea, vomiting or rectal irritation. These side effects usually subside in a few minutes.
Bisacodyl is only meant to be used in children over the age of 6 and adults.
Individuals who have hypersensitivity to Bisacodyl or any component of the formula should avoid this product.
Bisacodyl works by increasing peristalsis of the bowel walls and leads to increased motility. It also alters the water and electrolyte secretion producing net intestinal fluid loss and relaxation. Once the tablet is taken with water, it works within 6-10 hours. It is best to take the tablet at night on an empty stomach.
The tablet should not be crushed in the mouth but swallowed whole. The recommended dose is 5-10 mg, and one should not exceed more than 3 doses a day. One should avoid taking Bisacodyl with dairy or milk products as the absorption can be delayed. The drug has few mild side effects which include mild abdominal cramps, nausea, vomiting or rectal irritation. These side effects usually subside in a few minutes.
Bisacodyl is only meant to be used in children over the age of 6 and adults.
Individuals who have hypersensitivity to Bisacodyl or any component of the formula should avoid this product.
Isopropyl alcohol 70%
Isopropyl alcohol also known as rubbing alcohol is widely used in health care facilities and in outpatient clinics. It is classified as a sanitizer and rapidly kills a wide variety of organisms. Once applied on inanimate surfaces, it rapidly kills the bacteria and is the preferred solution to sanitize medical equipment.
In the emergency rooms and walk-in clinics, isopropyl alcohol is also used to clean and sanitize minor cuts, abrasion and small lacerations. The alcohol rapidly dries the skin, and rarely causes any pain.
In order to achieve sanitation, the alcohol is wiped on surfaces like door knobs, handles, toilets, walls cupboards and medical instruments. There are also sterile pads containing 70% isopropyl alcohol available which can be used to wipe surfaces clean. When large amounts of isopropyl alcohol are applied to skin, it can cause dryness and thus use of a skin moisturizer is recommended.
Isopropyl alcohol should be stored in a cool place and kept away from heat or open flames.
The biggest advantage of isopropyl alcohol is that it works rapidly and quickly evaporates. Most health care professionals consider it to be the antiseptic of choice for use in the home and in emergency rooms.
In the emergency rooms and walk-in clinics, isopropyl alcohol is also used to clean and sanitize minor cuts, abrasion and small lacerations. The alcohol rapidly dries the skin, and rarely causes any pain.
In order to achieve sanitation, the alcohol is wiped on surfaces like door knobs, handles, toilets, walls cupboards and medical instruments. There are also sterile pads containing 70% isopropyl alcohol available which can be used to wipe surfaces clean. When large amounts of isopropyl alcohol are applied to skin, it can cause dryness and thus use of a skin moisturizer is recommended.
Isopropyl alcohol should be stored in a cool place and kept away from heat or open flames.
The biggest advantage of isopropyl alcohol is that it works rapidly and quickly evaporates. Most health care professionals consider it to be the antiseptic of choice for use in the home and in emergency rooms.
Thursday, August 27, 2009
Saphris- a novel drug to treat schizophrenia and bipolar disorder: Part 2
In clinical trials sponsored by the manufacturers of Saphris, the most common side effects reported by schizophrenia patients were the lack of ability to sit still or remain motionless, diminished oral sensitivity, lethargy, drowsiness, and weight gain.
All atypical antipsychotic medications also carry a "black box" warning, the FDA's stringent warning, alerting health care prescribers about an increased risk of death linked to off-label use of these drugs to treat behavioral problems in elderly individuals with dementia-related psychosis. Saphris is not approved for such patients.
Saphris is made by Schering Plough. Experts at FDA evaluated the data from studies performed by the pharmaceutical company and feel that the drug is safe and effective. The drug will be formally approved for clinical use but will most likely be available for release in a few months.
Final word. Consumers should be aware that out of the three clinical trials sponsored by the pharmaceutical company, positive results were only seen in two out of three trials. No long-term data are available and neither is it known if Saphris works in all patients with Schizophrenia or bipolar disorder. Very little data on the drug is available. Only time will tell if the drug is as good as Schering Plough claims.
http://www.webmd.com/bipolar-disorder/news/20090814/fda-oks-new-schizophrenia-bipolar-drug
All atypical antipsychotic medications also carry a "black box" warning, the FDA's stringent warning, alerting health care prescribers about an increased risk of death linked to off-label use of these drugs to treat behavioral problems in elderly individuals with dementia-related psychosis. Saphris is not approved for such patients.
Saphris is made by Schering Plough. Experts at FDA evaluated the data from studies performed by the pharmaceutical company and feel that the drug is safe and effective. The drug will be formally approved for clinical use but will most likely be available for release in a few months.
Final word. Consumers should be aware that out of the three clinical trials sponsored by the pharmaceutical company, positive results were only seen in two out of three trials. No long-term data are available and neither is it known if Saphris works in all patients with Schizophrenia or bipolar disorder. Very little data on the drug is available. Only time will tell if the drug is as good as Schering Plough claims.
http://www.webmd.com/bipolar-disorder/news/20090814/fda-oks-new-schizophrenia-bipolar-drug
Saphris- a novel drug to treat schizophrenia and bipolar disorder: Part 1
Just a few weeks ago, the FDA approved a new drug called Saphris to treat schizophrenia and bipolar I disorder in adults. Saphris belongs to a class of drugs called atypical antipsychotics. The FDA accepted Saphris based on recent clinical trials in which the medication was much better than placebo at reducing symptoms in patients with schizophrenia and bipolar disorder.
Schizophrenia is a mental disorder that affects about 1% of North Americans and is one of the most common causes of suicide in these individuals. Schizophrenia can present with a range of symptoms that include hearing voices other people do not hear or having false beliefs that others are reading their minds, controlling their thoughts or scheming to harm them. Many schizophrenics are inappropriately suspicious or paranoid.
Bipolar disorder, also acknowledged as manic-depressive illness, is believed to affect about 1% to 3% of individuals in North America. Bipolar I disorder is a chronic, severe, and recurrent mental disorder that induces sporadic periods of depression and increased levels of hyperactivity, restlessness, competing thoughts, rapid speech, impulsive actions, and a diminished need for sleep.
Both schizophrenia and bipolar disorder not only affect the individual but also devastate relationships between families and friends. Despite years of research, the cause of both these disorders remains a puzzle. Even though there are drugs to treat these disorders, many individuals rapidly develop tolerance, have numerous side effects and treatment is life long. The use of drugs to treat schizophrenia and bipolar disorders is essential because they can help these individuals live more independently and even hold jobs.
Schizophrenia is a mental disorder that affects about 1% of North Americans and is one of the most common causes of suicide in these individuals. Schizophrenia can present with a range of symptoms that include hearing voices other people do not hear or having false beliefs that others are reading their minds, controlling their thoughts or scheming to harm them. Many schizophrenics are inappropriately suspicious or paranoid.
Bipolar disorder, also acknowledged as manic-depressive illness, is believed to affect about 1% to 3% of individuals in North America. Bipolar I disorder is a chronic, severe, and recurrent mental disorder that induces sporadic periods of depression and increased levels of hyperactivity, restlessness, competing thoughts, rapid speech, impulsive actions, and a diminished need for sleep.
Both schizophrenia and bipolar disorder not only affect the individual but also devastate relationships between families and friends. Despite years of research, the cause of both these disorders remains a puzzle. Even though there are drugs to treat these disorders, many individuals rapidly develop tolerance, have numerous side effects and treatment is life long. The use of drugs to treat schizophrenia and bipolar disorders is essential because they can help these individuals live more independently and even hold jobs.
Thursday, August 13, 2009
Can Tamoxifen be used to treat Bipolar Disorder? Part 2
In a recently published study from Turkey, close to 50% of manic patients who took the drug tamoxifen had fewer manic episodes during the three weeks of treatment, compared to just 5% of placebo-treated patients. About 25 percent of tamoxifen-treated patients and none of the placebo-treated patients achieved remissions.
At the end of three weeks of treatment, the tamoxifen-treated patients had markedly lower scores on clinical tests designed to measure severity of manic symptoms, while the scores of placebo-treated patients increased slightly. Tamoxifen-treated patients also required less lorazepam in the second and third weeks of the study.
The only negative of the study was that it only involved 50 patents. However, this is not the first study to show that tamoxifen decreases manic symptoms in individuals with bipolar disorder. A previous National Institute of Mental Health Study reported that 63% of patients had reduced manic symptoms when treated with tamoxifen after three weeks, compared to about less than 10 percent of placebo-treated patients.
Tamoxifen has been observed to be very safe for short-term use. Usually treatment for mania is only used for days or weeks, and once the mania is under control, individuals are then maintained on a variety of mood stabilizers.
The drug tamoxifen is quite effective but its estrogen inhibitory activity is worrisome in the long-term treatment of bipolar individuals. There is experimental evidence that long term use of tamoxifen may induce uterine cancer. That is why tamoxifen is not currently recommended for long-term use. There is currently a search for drugs like tamoxifen but do not have the ability to block estrogen receptors.
The above study will hopefully enable researchers to develop better and safer drugs to help treat bipolar treatments. Researchers are working to find similar drugs which target the exact PKC enzymes associated with mania.
The findings are published in the March issue of the Archives of General Psychiatry.
http://www.webmd.com/bipolar-disorder/news/20080303/tamoxifen-may-help-treat-bipolar-mania?page=2
At the end of three weeks of treatment, the tamoxifen-treated patients had markedly lower scores on clinical tests designed to measure severity of manic symptoms, while the scores of placebo-treated patients increased slightly. Tamoxifen-treated patients also required less lorazepam in the second and third weeks of the study.
The only negative of the study was that it only involved 50 patents. However, this is not the first study to show that tamoxifen decreases manic symptoms in individuals with bipolar disorder. A previous National Institute of Mental Health Study reported that 63% of patients had reduced manic symptoms when treated with tamoxifen after three weeks, compared to about less than 10 percent of placebo-treated patients.
Tamoxifen has been observed to be very safe for short-term use. Usually treatment for mania is only used for days or weeks, and once the mania is under control, individuals are then maintained on a variety of mood stabilizers.
The drug tamoxifen is quite effective but its estrogen inhibitory activity is worrisome in the long-term treatment of bipolar individuals. There is experimental evidence that long term use of tamoxifen may induce uterine cancer. That is why tamoxifen is not currently recommended for long-term use. There is currently a search for drugs like tamoxifen but do not have the ability to block estrogen receptors.
The above study will hopefully enable researchers to develop better and safer drugs to help treat bipolar treatments. Researchers are working to find similar drugs which target the exact PKC enzymes associated with mania.
The findings are published in the March issue of the Archives of General Psychiatry.
http://www.webmd.com/bipolar-disorder/news/20080303/tamoxifen-may-help-treat-bipolar-mania?page=2
Can Tamoxifen be used to treat Bipolar Disorder? Part 1
There are close to 6 million individuals in the US with bipolar disorder. This disorder characterized by severe mood shifts ranging from extreme mania to depression can create havoc in one’s life. Manic episodes may last anywhere from 7 days to several months and the symptoms may range from acute restlessness, trouble sleeping, anxiety, irritability, distractibility and/or paranoia. While the depressive episodes are treatable, the manic phases of bipolar disorders are very difficult to treat. The few drug treatments available to date have to be taken for many weeks and often fail to work or worsen the depression. Even when the treatment works, many individuals rapidly develop resistance to the drugs. During the manic phase of the disorder, individuals may lose their jobs, spend a lot of money, and have poor martial relationships.
For some years now, scientists have been trying to discover treatments that work faster and resolve the bipolar phase without causing excess depression.
Tamoxifen is a widely used drug to treat postmenopausal women who have had breast cancer. Tamoxifen has been used for more than two decades to treat breast cancer. It acts by blocking activity of the hormone estrogen, which stimulates breast cancer growth. Tamoxifen also inhibits a group of enzymes known as protein kinase C, and it was this activity that first fascinated scientists studying bipolar disorder.
Now, there is evidence that perhaps tamoxifen may be useful in the treatment of manic phase of bipolar disorder.
For some years now, scientists have been trying to discover treatments that work faster and resolve the bipolar phase without causing excess depression.
Tamoxifen is a widely used drug to treat postmenopausal women who have had breast cancer. Tamoxifen has been used for more than two decades to treat breast cancer. It acts by blocking activity of the hormone estrogen, which stimulates breast cancer growth. Tamoxifen also inhibits a group of enzymes known as protein kinase C, and it was this activity that first fascinated scientists studying bipolar disorder.
Now, there is evidence that perhaps tamoxifen may be useful in the treatment of manic phase of bipolar disorder.
Friday, August 7, 2009
Does Pregabalin (lyrica) relieve pain in Fibromyalgia? Part 2
The results
Symptomatic pain relief was achieved in patients at all doses of pregabalin when it was compared to the sugar pill. Further, patients with fibromyalgia also showed global mood improvement, and reported good sleeping scores. The two most common side effects of the drug observed in some patients were dizziness and sleepiness. These side effects were more common with higher doses of the drug.
This study supports the use of pregabalin for the treatment of pain and sleep disturbances in patients with fibromyalgia. The drug is relatively safe and does work in a significant majority of patients. However, one should be aware that Lyrica does not come cheap. The average cost for a 150 mg pill taken three times a day for a month ranges from $175-$200.
http://www.mdlinx.com/internalmdlinx/news-article.cfm/2388789
Symptomatic pain relief was achieved in patients at all doses of pregabalin when it was compared to the sugar pill. Further, patients with fibromyalgia also showed global mood improvement, and reported good sleeping scores. The two most common side effects of the drug observed in some patients were dizziness and sleepiness. These side effects were more common with higher doses of the drug.
This study supports the use of pregabalin for the treatment of pain and sleep disturbances in patients with fibromyalgia. The drug is relatively safe and does work in a significant majority of patients. However, one should be aware that Lyrica does not come cheap. The average cost for a 150 mg pill taken three times a day for a month ranges from $175-$200.
http://www.mdlinx.com/internalmdlinx/news-article.cfm/2388789
Does Pregabalin (lyrica) relieve pain in Fibromyalgia? Part 1
The treatment of fibromyalgia has been very disappointing. The disorder is difficult to diagnose, commonly under treated and even less appreciated among health care professionals. Despite decades of research, the pathology is not well understood and treatment is empirical. Most individuals go through a trial and error process until they finally discover something that works. Unfortunately, what may work in one individual generally fails to work in others.
Recently the drug pregabalin (lyrica) was studied to determine its effectiveness in patients with fibromyalgia. Pregabalin is an anti-seizure drug and frequently used to treat various types of pain disorders. Lyrica has also been found effective for generalized anxiety disorder. Pregabalin is marketed by Pfizer under the trade name Lyrica.
In the early 2000s, many anecdotal reports started to appear that Lyrica might be effective for the treatment of chronic pain in disorders such as fibromyalgia and spinal cord injury. Two years ago, pregabalin became the first medication approved by the U.S. Food and Drug Administration specifically for the treatment of fibromyalgia.
One of the reasons why pregabalin is widely prescribed is because it has very low potential for abuse, and has limited dependence liability if misused. It is classified as a Schedule V drug.
To determine whether Lyrica is effective in fibromyalgia, the drug was administered to 748 patients and compared to placebo (sugar pill). Pregabalin at doses of 300 mg/day, 450 mg/day or 600 mg/twice a day was studied for 13 weeks. Besides evaluating its efficacy, side effects, and safety profile of pregabalin was also assessed.
Recently the drug pregabalin (lyrica) was studied to determine its effectiveness in patients with fibromyalgia. Pregabalin is an anti-seizure drug and frequently used to treat various types of pain disorders. Lyrica has also been found effective for generalized anxiety disorder. Pregabalin is marketed by Pfizer under the trade name Lyrica.
In the early 2000s, many anecdotal reports started to appear that Lyrica might be effective for the treatment of chronic pain in disorders such as fibromyalgia and spinal cord injury. Two years ago, pregabalin became the first medication approved by the U.S. Food and Drug Administration specifically for the treatment of fibromyalgia.
One of the reasons why pregabalin is widely prescribed is because it has very low potential for abuse, and has limited dependence liability if misused. It is classified as a Schedule V drug.
To determine whether Lyrica is effective in fibromyalgia, the drug was administered to 748 patients and compared to placebo (sugar pill). Pregabalin at doses of 300 mg/day, 450 mg/day or 600 mg/twice a day was studied for 13 weeks. Besides evaluating its efficacy, side effects, and safety profile of pregabalin was also assessed.
Friday, July 31, 2009
Can Garlic prevent the Common Cold? Part 2
The Results
Overall, it was observed that individuals who took garlic had much fewer episodes of the common cold compared to individuals who took the sugar pill. Further, the number of days of illness was lower in the garlic group. However, the number of days to recovery was similar in both groups.
Overall, garlic ingestion was deemed safe but few individuals did develop a rash. On the other hand, many individuals had complaints of bad breath.
So what about the consumer?
This was only one trial and only limited conclusions can be drawn. All the data are self-reported and there are always inherent errors in such a study. Statements of effectiveness to date are based on weak quality evidence. Garlic pills are relatively cheap and one does not require a prescription. Therefore, if you have a cold, the choice is simple. Either drink fluids, rest, and perhaps take an over the counter medication or take garlic, have fewer episodes of the common cold and have bad breath. At the moment, there are no data from randomized controlled trials about whether taking garlic at the time of a cold diminishes either symptom intensity or number of days of illness. http://www.cochrane.org/reviews/en/ab006206.html
For more on personal care and medical products, please visit www.medexsupply.com
Overall, it was observed that individuals who took garlic had much fewer episodes of the common cold compared to individuals who took the sugar pill. Further, the number of days of illness was lower in the garlic group. However, the number of days to recovery was similar in both groups.
Overall, garlic ingestion was deemed safe but few individuals did develop a rash. On the other hand, many individuals had complaints of bad breath.
So what about the consumer?
This was only one trial and only limited conclusions can be drawn. All the data are self-reported and there are always inherent errors in such a study. Statements of effectiveness to date are based on weak quality evidence. Garlic pills are relatively cheap and one does not require a prescription. Therefore, if you have a cold, the choice is simple. Either drink fluids, rest, and perhaps take an over the counter medication or take garlic, have fewer episodes of the common cold and have bad breath. At the moment, there are no data from randomized controlled trials about whether taking garlic at the time of a cold diminishes either symptom intensity or number of days of illness. http://www.cochrane.org/reviews/en/ab006206.html
For more on personal care and medical products, please visit www.medexsupply.com
Can Garlic prevent the Common Cold? Part 1
One of the most popular health supplements that has often been hyped up to treat almost every medical disorder under the sun is garlic. For decades, garlic has been sold by health food stores in every type of formulation. There are pills, tablets, lotions, liquids, potions, pastes, and even creams containing garlic. Garlic mania has hit North America and is getting stronger every day. For decades, one medical disorder which garlic has been most frequently used to treat is the common cold.
The common cold is associated with a high rate of morbidity and is one of the most common reasons why people take off from work during winter months. On average, children have at least 4-6 cold a year and some adults have at least 2-4 colds a year. Many individuals take garlic based on the belief that it has good anti bacterial and anti viral properties.
Consumers spend an enormous amount of money on health supplements, many of which have no relevant clinical data to back up the claims made by the vendors. Therefore, the question is, “Can garlic supplements prevent or treat the common cold?”
Recently, Cochrane Reviews conducted analysis of the literature to determine whether garlic (allium sativum) was effective for either prevention or treatment of the common cold, when compared to placebo or no treatment. From the literature, only one randomized trial study comprising 146 participants was evaluated since it met the criteria. Individual took 180 mg of allicin garlic for 12 weeks and self reported their symptoms.
The common cold is associated with a high rate of morbidity and is one of the most common reasons why people take off from work during winter months. On average, children have at least 4-6 cold a year and some adults have at least 2-4 colds a year. Many individuals take garlic based on the belief that it has good anti bacterial and anti viral properties.
Consumers spend an enormous amount of money on health supplements, many of which have no relevant clinical data to back up the claims made by the vendors. Therefore, the question is, “Can garlic supplements prevent or treat the common cold?”
Recently, Cochrane Reviews conducted analysis of the literature to determine whether garlic (allium sativum) was effective for either prevention or treatment of the common cold, when compared to placebo or no treatment. From the literature, only one randomized trial study comprising 146 participants was evaluated since it met the criteria. Individual took 180 mg of allicin garlic for 12 weeks and self reported their symptoms.
Neosynephrine: Part 2
What is concentration of nasal Neosynephrine Available?
As a nasal spray, phenylephrine is available in 1 percent and 0.5 percent concentrations. In a few cases, rebound of congestion occurs when Neosynephrine is abruptly discontinued.
What other products contain Neosynephrine?
- Alka-Seltzer Cold Effervescent formulation
- Sudafed PE Non-Drowsy Nasal Decongestant
- Robitussin CF, Tylenol Sinus
- DayQuil Capsules.
- Tylenol Sinus Congestion & Pain
- Dristan
- Theraflu
- Benadryl Allergy & Sinus Headache
- Excedrin Sinus Headache
What should I avoid while taking Neo-Synephrine?
Even though nasal Neosynephrine is safe, one should use caution while driving or operating any heavy machinery. Neosynephrine can sometimes cause dizziness, drowsiness or impair concentration. One should not take more than the recommended dose on the package.
What happens if I miss a dose of Neosynephrine?
If you miss a dose of Neosynephrine, never double dose at the next timed scheduled. If you miss the dose within one hour of the scheduled time, you can continue using the medication.
Who should not use Neosynephrine?
Neosynephrine has not been well studied in pregnant females and those who are breast-feeding. To avoid harm to the baby, it is highly recommended that Neosynephrine not be used if one is pregnant or breast feeding
What is cost of Nasal Neosynephrine?
Bayer Neo-synephrine nasal strength (1/4%), 15 ml averages $10.
For more on Neosynephrine, please visit www.medexsupply.com
As a nasal spray, phenylephrine is available in 1 percent and 0.5 percent concentrations. In a few cases, rebound of congestion occurs when Neosynephrine is abruptly discontinued.
What other products contain Neosynephrine?
- Alka-Seltzer Cold Effervescent formulation
- Sudafed PE Non-Drowsy Nasal Decongestant
- Robitussin CF, Tylenol Sinus
- DayQuil Capsules.
- Tylenol Sinus Congestion & Pain
- Dristan
- Theraflu
- Benadryl Allergy & Sinus Headache
- Excedrin Sinus Headache
What should I avoid while taking Neo-Synephrine?
Even though nasal Neosynephrine is safe, one should use caution while driving or operating any heavy machinery. Neosynephrine can sometimes cause dizziness, drowsiness or impair concentration. One should not take more than the recommended dose on the package.
What happens if I miss a dose of Neosynephrine?
If you miss a dose of Neosynephrine, never double dose at the next timed scheduled. If you miss the dose within one hour of the scheduled time, you can continue using the medication.
Who should not use Neosynephrine?
Neosynephrine has not been well studied in pregnant females and those who are breast-feeding. To avoid harm to the baby, it is highly recommended that Neosynephrine not be used if one is pregnant or breast feeding
What is cost of Nasal Neosynephrine?
Bayer Neo-synephrine nasal strength (1/4%), 15 ml averages $10.
For more on Neosynephrine, please visit www.medexsupply.com
Neosynephrine: Part 1
What is Neosynephrine?
Neosynephrine (phenylephrine) is a decongestant readily available over the counter without a prescription. The drug acts by shrinking blood vessels in the chest, nose, and sinuses. This helps decrease secretions from the nose and sinuses and reduces congestion.
What can Neosynephrine be used to treat?
Neosynephrine is available in various formulations including a pill, injection and a nasal spray. Consumers usually take Neosynephrine to treat allergies, hay fever, sinus irritation, and symptoms of a common cold.
In the hospital setting, Neosynephrine is sometimes used to treat low blood pressure and increase heart rate.
What are side effects of Neosynephrine?
Side effects with nasal Neosynephrine are quite rare. A Few side effects reported include the following:
- Allergic reaction that may result in difficult
breathing, swelling of the lips or tongue
- Appearance of hives or itching
- Fast heart rate
- Anxiety or hallucinations
- Lightheadedness
- Lack of sleep
- Headache
- Nausea
- Sweating
- Seizures
Most of these side effects are transient and usually resolve when the drug is discontinued
What are precautions one should take when using Neosynephrine?
Neosynephrine is best avoided in individuals who take anti depressants of the monoamine oxidase inhibitor class. Always inform your physician if you have high blood pressure, are diabetic or using another decongestant prior to starting Neosynephrine
Neosynephrine (phenylephrine) is a decongestant readily available over the counter without a prescription. The drug acts by shrinking blood vessels in the chest, nose, and sinuses. This helps decrease secretions from the nose and sinuses and reduces congestion.
What can Neosynephrine be used to treat?
Neosynephrine is available in various formulations including a pill, injection and a nasal spray. Consumers usually take Neosynephrine to treat allergies, hay fever, sinus irritation, and symptoms of a common cold.
In the hospital setting, Neosynephrine is sometimes used to treat low blood pressure and increase heart rate.
What are side effects of Neosynephrine?
Side effects with nasal Neosynephrine are quite rare. A Few side effects reported include the following:
- Allergic reaction that may result in difficult
breathing, swelling of the lips or tongue
- Appearance of hives or itching
- Fast heart rate
- Anxiety or hallucinations
- Lightheadedness
- Lack of sleep
- Headache
- Nausea
- Sweating
- Seizures
Most of these side effects are transient and usually resolve when the drug is discontinued
What are precautions one should take when using Neosynephrine?
Neosynephrine is best avoided in individuals who take anti depressants of the monoamine oxidase inhibitor class. Always inform your physician if you have high blood pressure, are diabetic or using another decongestant prior to starting Neosynephrine
Sunday, May 31, 2009
Cylapril: part 2
How does cylapril work?
Manufacturers of cylapril claim that people who drink coffee or alcohol desensitize the body to effects of adrenal hormones. Cylapril inhibits this barrier and restarts the energy supply.
How is cylapril sold?
Cylapril comes as a two-stage formulation. The first formula helps restore nutrients needed for the adrenal gland and the second formula helps to revitalize and boost the energy.
Can cylapril be used as a replacement for the adrenal hormone?
Not. Cylapril is not a replacement for any hormone in the body. It does nothing to the adrenal gland. Mucking around with the adrenal gland with unknown pills and without supervision from a health care professional can be lethal
How does cylapril formula work?
It does not work. Forget the BS the manufacturers provide. In fact, the FDA has recently warned the company to stop making false claims. There is no ingredient in cylapril that can affect the adrenal gland.
Has cylapril been tested in humans?
No, it has not been tested in a single human. All claims are made by people who have a vested interest in this product.
Are there testimonials about cylapril?
Sure, all testimonials claim it is a rip off. Once you have bought the pills, you have no refunds, no guarantee, and no one to complain to.
Are there any special ingredients in cylapril?
There is nothing special in Cylapril that can help you lose weight or boost your energy. Sure, the formula contains bees wax. The company claims that bees Wax helps the brain relax, reduces anxiety, tension and fatigue. Bees wax also postulated to protect the adrenal gland from further stress related injury and allows the gland to recover. The last I heard is that the bee population in North America is rapidly dying- so bees wax cannot be all that great.
Final point
Cylapril is nothing more than a scam. The company is now being investigated by FDA because of falsified claims. For all consumers, please read the testimonials about this product before you buy this expensive pill. The only thing guaranteed with cylapril is that you will have spent your money on more junk pills.
Manufacturers of cylapril claim that people who drink coffee or alcohol desensitize the body to effects of adrenal hormones. Cylapril inhibits this barrier and restarts the energy supply.
How is cylapril sold?
Cylapril comes as a two-stage formulation. The first formula helps restore nutrients needed for the adrenal gland and the second formula helps to revitalize and boost the energy.
Can cylapril be used as a replacement for the adrenal hormone?
Not. Cylapril is not a replacement for any hormone in the body. It does nothing to the adrenal gland. Mucking around with the adrenal gland with unknown pills and without supervision from a health care professional can be lethal
How does cylapril formula work?
It does not work. Forget the BS the manufacturers provide. In fact, the FDA has recently warned the company to stop making false claims. There is no ingredient in cylapril that can affect the adrenal gland.
Has cylapril been tested in humans?
No, it has not been tested in a single human. All claims are made by people who have a vested interest in this product.
Are there testimonials about cylapril?
Sure, all testimonials claim it is a rip off. Once you have bought the pills, you have no refunds, no guarantee, and no one to complain to.
Are there any special ingredients in cylapril?
There is nothing special in Cylapril that can help you lose weight or boost your energy. Sure, the formula contains bees wax. The company claims that bees Wax helps the brain relax, reduces anxiety, tension and fatigue. Bees wax also postulated to protect the adrenal gland from further stress related injury and allows the gland to recover. The last I heard is that the bee population in North America is rapidly dying- so bees wax cannot be all that great.
Final point
Cylapril is nothing more than a scam. The company is now being investigated by FDA because of falsified claims. For all consumers, please read the testimonials about this product before you buy this expensive pill. The only thing guaranteed with cylapril is that you will have spent your money on more junk pills.
Cylapril- another weight loss pill or SCAM?
Cylapril is a non-prescription pill that is hyped up to help boost your energy and revitalize your body. In the process, you will also lose weight
How does cylapril work?
Manufacturers of Cylapril claim that the pill works by stimulating the adrenal glands. This results in synthesis of hormones which helps the body fight stress.
What are the adrenal glands?
The adrenals are tiny glands located just above the kidney. These small glands are vital for proper metabolism, manufacture of both male and female sex hormones, modulate libido, produce corticosteroids, and help boost the body’s immunity. The adrenals are under complex control by the brain.
What happens when the adrenals do not function well?
In some rare individuals, adrenal glands do not function normally and the individual will feel tired, sleepy, gain weight, and have abnormal levels of sugar, sodium, and potassium. The adrenals respond to stress quite well and when the glands under functions, one can develop life-threatening infections.
To counteract the under activity of adrenal glands, now there is cylapril
Does Cylapril help one lose weight?
If you listen to the manufacturers, the pill is supposed to be magical. It can do many things. In reality, it is garbage. The manufacturers suggest that one take the pill every day and it helps burn fat. As the fat is reduced, calories are burnt and one loses weight. Actually, it does no such thing. No one loses weight – the only thing lost is your money.
How does cylapril work?
Manufacturers of Cylapril claim that the pill works by stimulating the adrenal glands. This results in synthesis of hormones which helps the body fight stress.
What are the adrenal glands?
The adrenals are tiny glands located just above the kidney. These small glands are vital for proper metabolism, manufacture of both male and female sex hormones, modulate libido, produce corticosteroids, and help boost the body’s immunity. The adrenals are under complex control by the brain.
What happens when the adrenals do not function well?
In some rare individuals, adrenal glands do not function normally and the individual will feel tired, sleepy, gain weight, and have abnormal levels of sugar, sodium, and potassium. The adrenals respond to stress quite well and when the glands under functions, one can develop life-threatening infections.
To counteract the under activity of adrenal glands, now there is cylapril
Does Cylapril help one lose weight?
If you listen to the manufacturers, the pill is supposed to be magical. It can do many things. In reality, it is garbage. The manufacturers suggest that one take the pill every day and it helps burn fat. As the fat is reduced, calories are burnt and one loses weight. Actually, it does no such thing. No one loses weight – the only thing lost is your money.
Saturday, May 16, 2009
Can I lose weight with diuretics?
Diuretics are also known as water pills. These medications are widely used in medicine and valuable in the treatment of many medical disorders. There are many types of diuretics and they all work in the same way. Diuretics are medications that can get rid of excess body water. The two most common medical disorders treated with diuretics are high blood pressure and congestive heart failure. Water loss occurs gradually and the water pills are generally safe. All individuals who take water pills must be monitored by a physician because serious changes in electrolyte levels can occur.
Over the years, many athletes have resorted to using water pills to lose weight.
Sure, you can lose weight with diuretics but these medications are not recommended for that purpose.
When water pills are used by athletes, the weight loss is immediate, small and is mostly water. The water is easily gained in a day or two once you stop taking the medication. There is no water pill that will help you lose fat or your cellulite.
Athletes generally take diuretics to get to a certain weight before a sports meeting. This is not recommended as the water pill usually causes excessive dehydration- resulting in a poor performance in sports.
If you want to lose weight, eat less and start walking. The more pills you take, the higher chance of complications.
Over the years, many athletes have resorted to using water pills to lose weight.
Sure, you can lose weight with diuretics but these medications are not recommended for that purpose.
When water pills are used by athletes, the weight loss is immediate, small and is mostly water. The water is easily gained in a day or two once you stop taking the medication. There is no water pill that will help you lose fat or your cellulite.
Athletes generally take diuretics to get to a certain weight before a sports meeting. This is not recommended as the water pill usually causes excessive dehydration- resulting in a poor performance in sports.
If you want to lose weight, eat less and start walking. The more pills you take, the higher chance of complications.
Wednesday, May 6, 2009
Penciclovir- another drug for herpes?
What is mystifying is why so many doctors write a prescription for topical acyclovir when it really does not help at all! Anyone who buys topical acyclovir for herpes is a fool- it is expensive and does nothing for your herpes infection. Because topical acyclovir is useless for the treatment of herpes infection, there is now a new product released.
Penciclovir is similar to acyclovir and indicated for the treatment of various herpes infections. The drug is available as a 1% cream and the pharmaceutical company claims that it is better able to penetrate the skin than acyclovir.
So far, acyclovir has been an abysmal failure when it comes to treatment of herpes sores. The authors of the recent study claim that Penciclovir readily gets absorbed and reaches skin in high concentrations and thus, it is more effective.
One should note that all these studies were done in a laboratory. Whether Penciclovir actually works better than acyclovir in the clinical situation remains to be seen. So far, there are not many testimonials but anecdotal reports from patients indicate that it is no better than acyclovir.
Penciclovir is available in most pharmacies and requires a prescription. The drug is recommended for treatment of herpes sores anywhere on the body.
The cost of drug varies from $30-$50 (not sure why there is such a large variation in pricing!).
For the moment, one should not rush to buy this product. There is little information on whether it really does anything. Remember, the drug company is out there to make money and some doctors who actually brag about the drug are paid by the company. A wait and see approach is important. Moreover, do not worry; your herpes is not going anywhere yet.
Penciclovir is similar to acyclovir and indicated for the treatment of various herpes infections. The drug is available as a 1% cream and the pharmaceutical company claims that it is better able to penetrate the skin than acyclovir.
So far, acyclovir has been an abysmal failure when it comes to treatment of herpes sores. The authors of the recent study claim that Penciclovir readily gets absorbed and reaches skin in high concentrations and thus, it is more effective.
One should note that all these studies were done in a laboratory. Whether Penciclovir actually works better than acyclovir in the clinical situation remains to be seen. So far, there are not many testimonials but anecdotal reports from patients indicate that it is no better than acyclovir.
Penciclovir is available in most pharmacies and requires a prescription. The drug is recommended for treatment of herpes sores anywhere on the body.
The cost of drug varies from $30-$50 (not sure why there is such a large variation in pricing!).
For the moment, one should not rush to buy this product. There is little information on whether it really does anything. Remember, the drug company is out there to make money and some doctors who actually brag about the drug are paid by the company. A wait and see approach is important. Moreover, do not worry; your herpes is not going anywhere yet.
Thursday, April 30, 2009
Oxybutynin Gel 10% for Overactive Bladder part 2
Gelnique formulation is a colorless, fragrance free solution that contains some alcohol. It dries up quickly once applied on the skin. The dose of Gelnique is 1 g (1 ml) applied once a day. The gel may be applied on the thighs, abdomen, upper arms, or shoulder. Once Gelnique is applied on skin, there is constant absorption over the next 24 hours, resulting in a constant effect with minimal side effects.
Further studies have shown that absorption of Gelnique from the skin is not affected by showering 1 hour later or by applying sunscreen 30 minutes before or after applying the drug.
Gelnique is not recommended for use in individuals who have or at risk of developing
- urinary retention
- men with prostatic hypertrophy
- individuals with gastroparesis
- individuals with uncontrolled narrow angle glaucoma
- individual with allergy to the agent
Other medical disorders where the oxybutynin should be used with caution is in individuals with impairment of liver, kidney, muscle paralysis, ulcerative colitis, constipation, or reflux.
Because the gel can be transferred from human to human by vigorous skin to skin contact at the application site, washing of hands and avoidance of close contact with children is recommended for the first few hours. Since the drug is made in an alcoholic solution, one should avoid smoking, or close contact with heating or fire appliance until the gel is completely dry.
Further studies have shown that absorption of Gelnique from the skin is not affected by showering 1 hour later or by applying sunscreen 30 minutes before or after applying the drug.
Gelnique is not recommended for use in individuals who have or at risk of developing
- urinary retention
- men with prostatic hypertrophy
- individuals with gastroparesis
- individuals with uncontrolled narrow angle glaucoma
- individual with allergy to the agent
Other medical disorders where the oxybutynin should be used with caution is in individuals with impairment of liver, kidney, muscle paralysis, ulcerative colitis, constipation, or reflux.
Because the gel can be transferred from human to human by vigorous skin to skin contact at the application site, washing of hands and avoidance of close contact with children is recommended for the first few hours. Since the drug is made in an alcoholic solution, one should avoid smoking, or close contact with heating or fire appliance until the gel is completely dry.
Oxybutynin Gel 10% for Overactive Bladder
Overactive bladder affects nearly 33 million individuals in North America. Both men and women are equally affected, but more severe symptoms occur much early in women. Symptoms of overactive bladder include urinary urgency, frequency, and frequent urination at night. These symptoms often lead to a poor quality of life, depression, isolation, and long term disability. There are many treatments for overactive bladder but most pills also have side effects.
Recently, the FDA approved use of Oxybutynin chloride gel (10%) for the treatment of overactive bladder. Oxybutynin (Gelnique) acts like an anti spasmodic agent and offers patients with overactive bladder a better method to control their disorder. By relaxing the bladder muscles, oxybutynin helps diminish the strong urge to urinate all the time.
When Gelnique was evaluated in a recent clinical trial, it was shown to be quite efficacious and had minimal side effects. Applying the drug as paste led to better patient compliance. In a recent 12-weeks double blind trial, the gel was compared to a sugar formula and most patients has decreased incontinence episodes, less urinary frequency and urgency.
Oxybutynin is applied on skin as a gel and thus it bypasses the liver. This leads to much fewer side effects – that are commonly seen when the drug is administered as a pill. Most patients in the trial had significantly fewer episodes of dry mouth and constipation when the topical formula was used.
Recently, the FDA approved use of Oxybutynin chloride gel (10%) for the treatment of overactive bladder. Oxybutynin (Gelnique) acts like an anti spasmodic agent and offers patients with overactive bladder a better method to control their disorder. By relaxing the bladder muscles, oxybutynin helps diminish the strong urge to urinate all the time.
When Gelnique was evaluated in a recent clinical trial, it was shown to be quite efficacious and had minimal side effects. Applying the drug as paste led to better patient compliance. In a recent 12-weeks double blind trial, the gel was compared to a sugar formula and most patients has decreased incontinence episodes, less urinary frequency and urgency.
Oxybutynin is applied on skin as a gel and thus it bypasses the liver. This leads to much fewer side effects – that are commonly seen when the drug is administered as a pill. Most patients in the trial had significantly fewer episodes of dry mouth and constipation when the topical formula was used.
Tuesday, April 28, 2009
How long can one take Viagra?
The two drugs for erectile dysfunction are Viagra and cialis. Recently there was an announcement that perhaps when these drugs were taken for a long time, it could lead to vision loss. However, now there is good news. If you got the money to buy Viagra or cialis, you can safely continue to use these two drugs without having to worry about your vision.
There was recent concern that use of drugs like Viagra could lead to impairment of vision or decreased vision at night. Some individuals also complained of blue vision. A recent study revealed that both drugs are safe and do not cause a higher vision loss compared to people who do not take Viagra. A well-controlled study did follow 244 men who took cialis or Viagra daily for 6 months (lucky guys had free Viagra because of the study). The study carefully analyzed vision and found no difference between those who took the drugs and those who took a sugar pill.
So for the time being 5 mg of cialis or 50 mg Viagra appear to be safe for men who can afford to take these pills everyday for 6 months. There are no data on women on take Viagra but if men have no problems, then I guess women should also be fine.
There was recent concern that use of drugs like Viagra could lead to impairment of vision or decreased vision at night. Some individuals also complained of blue vision. A recent study revealed that both drugs are safe and do not cause a higher vision loss compared to people who do not take Viagra. A well-controlled study did follow 244 men who took cialis or Viagra daily for 6 months (lucky guys had free Viagra because of the study). The study carefully analyzed vision and found no difference between those who took the drugs and those who took a sugar pill.
So for the time being 5 mg of cialis or 50 mg Viagra appear to be safe for men who can afford to take these pills everyday for 6 months. There are no data on women on take Viagra but if men have no problems, then I guess women should also be fine.
Monday, April 27, 2009
Epiduo Gel: promising drug for Acne part 2
The incidence of side effects with Epiduo gel was minimal and only 2% of individual had to discontinue the medication. The study revealed that Epiduo was well tolerated. The only side effects were minor skin redness and irritation.
Epiduo is very easy to use. A thin film should be applied on face, back, or upper arms after showering. If redness or skin irritation occurs, the drug should be discontinued for a few days.
Epiduo should not be used on skin that has been cut; sun burnt or if there is an infection. The gel should be avoided around eyes, nose, mouth and mucus membranes. After application of Epiduo, one should wear a sunscreen and avoid intense sunlight.
Final point: Epiduo does look to be a promising drug for acne. The drug is readily available but is somewhat expensive. The 45 g gel requires a prescription and costs about $50-$60.
For those individuals who have no more money to spend but already have topical accutane, perhaps they many want to combine it with benzyl peroxide for the best results. Benzyl peroxide is readily available without a prescription and is relatively cheap
Epiduo is very easy to use. A thin film should be applied on face, back, or upper arms after showering. If redness or skin irritation occurs, the drug should be discontinued for a few days.
Epiduo should not be used on skin that has been cut; sun burnt or if there is an infection. The gel should be avoided around eyes, nose, mouth and mucus membranes. After application of Epiduo, one should wear a sunscreen and avoid intense sunlight.
Final point: Epiduo does look to be a promising drug for acne. The drug is readily available but is somewhat expensive. The 45 g gel requires a prescription and costs about $50-$60.
For those individuals who have no more money to spend but already have topical accutane, perhaps they many want to combine it with benzyl peroxide for the best results. Benzyl peroxide is readily available without a prescription and is relatively cheap
Epiduo Gel: promising drug for Acne
Recently, FDA approved release of Epiduo, a gel for the treatment of acne vulgaris. The treatment of acne has never been satisfactory; many drugs have come and gone. Of all the drugs for acne, Retinoids have had the best success rate. Now we have a new product to help fight acne.
Epiduo is formulated with adapalene (0.1%) and benzyl peroxide (2.5 %,). Epiduo Gel is a relatively novel topical acne treatment that has been shown to be very effective for the treatment of inflammatory acne. Adapalene is a chemical that acts like a retinoid (Vitamin A). When combined with benzyl peroxide, the formulation can prevent infection, peel off old skin, and stimulate synthesis of fresh, younger, looking skin.
At present, there is no topical agent that is effective for acne. Epiduo gel is supposed to be applied once a day. This combination of a retinoid, adapalene, and benzyl peroxide, is claimed to be unique and very effective for certain types of acne.
The manufacturers of this product claim that this combination is very effective for mild and moderate inflamed acne. One study revealed that within the first week, nearly 18% of individuals had complete eradication of acne. By the end of 12 weeks, there was a 50 percent reduction in acne lesions. Further, this combination worked faster and without side effects.
Epiduo is formulated with adapalene (0.1%) and benzyl peroxide (2.5 %,). Epiduo Gel is a relatively novel topical acne treatment that has been shown to be very effective for the treatment of inflammatory acne. Adapalene is a chemical that acts like a retinoid (Vitamin A). When combined with benzyl peroxide, the formulation can prevent infection, peel off old skin, and stimulate synthesis of fresh, younger, looking skin.
At present, there is no topical agent that is effective for acne. Epiduo gel is supposed to be applied once a day. This combination of a retinoid, adapalene, and benzyl peroxide, is claimed to be unique and very effective for certain types of acne.
The manufacturers of this product claim that this combination is very effective for mild and moderate inflamed acne. One study revealed that within the first week, nearly 18% of individuals had complete eradication of acne. By the end of 12 weeks, there was a 50 percent reduction in acne lesions. Further, this combination worked faster and without side effects.
Friday, April 24, 2009
A look at weight loss drugs part 2
To fight the battle of bulge, physicians have only a few drugs to choose from. Some of these drugs are only recommended for short-term use because their long-term side effects remain unknown. Many weight loss experts claims that obese individuals can benefit from weight loss drugs. It is estimated that at least 25% of individuals who are obese may benefit from drug therapy.
The majority of weight loss drugs are derivatives or related to the central nervous stimulant- amphetamine. In the 60s and 70s, it was observed that individuals who took amphetamine and cocaine developed loss of appetite and weight loss. Soon the pharmaceutical companies developed analogues of drugs resembling amphetamine. In the 60s, little was know about addiction and physical dependence. Further, lawyers were not into malpractice at that time and thus, these drugs were used freely. Well, things soon began to change and by the 80s and 90s; lawyers knew there was money to be made in medicine and use of weight drugs declined in the 90s. Today, many lawyers know more about medical practice than physicians.
Besides amphetamine like drugs, other drugs that have been used for weight loss are diuretics and thyroid hormone. Both these drugs are not medically indicated for weight loss, but many patients self prescribe these drug for such use. With better understanding of obesity in the 1980s, different weight loss drugs were manufactured. Drugs like fen-phen helped individuals reduce weight loss, but the drug was associated with serious cardiac side effects and its use has been banned universally.
Since then, two new drugs with different mechanisms of action have been approved for use by the FDA. Sibutramine (Meridia) is a serotonin-norepinephrine reuptake inhibitor acts on the appetite center in the brain, and Orlistat (Xenical) is a pancreatic lipase inhibitor and inhibits the absorption of fat from the abdomen. However, these drugs do have side effects and their long term complications remain unknown. At present we have a huge gap in our armamentarium to treat obesity.
The majority of weight loss drugs are derivatives or related to the central nervous stimulant- amphetamine. In the 60s and 70s, it was observed that individuals who took amphetamine and cocaine developed loss of appetite and weight loss. Soon the pharmaceutical companies developed analogues of drugs resembling amphetamine. In the 60s, little was know about addiction and physical dependence. Further, lawyers were not into malpractice at that time and thus, these drugs were used freely. Well, things soon began to change and by the 80s and 90s; lawyers knew there was money to be made in medicine and use of weight drugs declined in the 90s. Today, many lawyers know more about medical practice than physicians.
Besides amphetamine like drugs, other drugs that have been used for weight loss are diuretics and thyroid hormone. Both these drugs are not medically indicated for weight loss, but many patients self prescribe these drug for such use. With better understanding of obesity in the 1980s, different weight loss drugs were manufactured. Drugs like fen-phen helped individuals reduce weight loss, but the drug was associated with serious cardiac side effects and its use has been banned universally.
Since then, two new drugs with different mechanisms of action have been approved for use by the FDA. Sibutramine (Meridia) is a serotonin-norepinephrine reuptake inhibitor acts on the appetite center in the brain, and Orlistat (Xenical) is a pancreatic lipase inhibitor and inhibits the absorption of fat from the abdomen. However, these drugs do have side effects and their long term complications remain unknown. At present we have a huge gap in our armamentarium to treat obesity.
A look at weight loss drugs
There is no doubt that certain drugs can help individuals lose weight. However, all consumers should understand that drugs are not the magic bullet for weight loss. One must compliment drugs with life style changes for the best response.
The major problem with our society is that everyone wants an easy way to weight loss- popping a pill without making any effort. The problem with weight gain is not in the stomach but with the psyche. One needs a treatment to motivate people to start walking.
All over the globe, waistlines are increasing and obesity is endemic. The pharmaceutical companies are trying desperately hard to come up with a decent drug because they know there is money to be made. However, since the fen fen fiasco, the resulting litigations have tempered the urge of all pharmaceutical companies to quickly release another product.
There are many drugs on the market that can help individuals lose weight, but the point is that almost each and every one of these drugs has disturbing side effects. Some drugs are addictive and yet others can even damage the body. The other reason why weight loss drugs are not prescribed frequently is because physicians have become targets of both patients and FDA. Whenever a complication results, physicians are the first to be sued. Second, the FDA tends to believe that physicians are prescribing way too many drugs and contribute to the burgeoning problems of addiction in society (true when it comes to pain pill prescriptions).
The major problem with our society is that everyone wants an easy way to weight loss- popping a pill without making any effort. The problem with weight gain is not in the stomach but with the psyche. One needs a treatment to motivate people to start walking.
All over the globe, waistlines are increasing and obesity is endemic. The pharmaceutical companies are trying desperately hard to come up with a decent drug because they know there is money to be made. However, since the fen fen fiasco, the resulting litigations have tempered the urge of all pharmaceutical companies to quickly release another product.
There are many drugs on the market that can help individuals lose weight, but the point is that almost each and every one of these drugs has disturbing side effects. Some drugs are addictive and yet others can even damage the body. The other reason why weight loss drugs are not prescribed frequently is because physicians have become targets of both patients and FDA. Whenever a complication results, physicians are the first to be sued. Second, the FDA tends to believe that physicians are prescribing way too many drugs and contribute to the burgeoning problems of addiction in society (true when it comes to pain pill prescriptions).
Monday, April 20, 2009
Zyatrim: Another junk weight loss pill? part 2
Zyatrim is heavily marketed as a revolutionary weight loss pill available without a prescription. It is claimed to be thermogenic, meaning it can dissolve fat and generate calories. The manufacturers use fancy names like apoptosis meaning that it induces the fat cells to die prematurely and Voila, you become thin in a few hours. The pill is supposed to be taken twice a day. One takes Zyatrim until the desired weight is reached.
The website claims that the weight loss induced by Zyatrim is permanent because the fat cells are destroyed for ever. And what is astonishing is that it starts to work within one hour.
What is even more incredible is that this so called reputable company also has a whole page where it trashes every other weight loss pill. Not a very professional way to conduct a business. If Zyatrim worked, why not let it effectiveness do the talking? And just to add some more information- Zyatrim is not approved by the FDA.
The ingredients listed in Zyatrim are extracts of Acacia Rigidula. Acacia Rigidula is a tree which grows in Central America, including Mexico. For decades it was observed that this plant was eaten by the wild goats that never got fat. Other ingredients that have been extracted from this tree and included in the formulation include methylsynephrine, phenylethylamine, Cassis nomane, theobromine, Yohimbine and ECGC. This combination is said to reverse the weight gain.
What does Zyatrim cost?
A month’s supply of Zyatrim is only $50, of course the more you buy the bigger the discounts (if a pill worked that great, would any company sell it for less, especially a weight loss pill?).
Now to the facts. There is ZERO evidence that Zyatrim works. There are no clinical trials nor is there a single piece of scientific information which can back up claims made by the manufacturer of Zyatrim. In fact, all over cyberspace there are many individuals whose testimony counters what the manufacturers says. The refund policy is dubious and money is never refunded. The ingredients listed are nothing special. These ingredients have been around for centuries and asides from working like a caffeinated product do nothing else.
Does anyone really believe that the FDA would allow a weight loss product to be sold online without a prescription if the above listed ingredients listed were present? Despite reports that extracts of this tree contain potent alkaloids and other chemicals, these results have never been verified in a scientific laboratory and are considered to be a hoax. There is no mention of Zyatrim in any scientific research study.
The economy is difficult today and in such times there are always charlatans who prey on other people’s hopes and dreams. Zyatrim is not the pill you should take to lose weight. The plant, Acacia Rigidula., from which Zyatrim is derived, is best left for the wild goats in Mexico. In other words- it is CRAP.
If you want to lose weight, start walking more, eat less and avoid dubious products like Zyatrim. This proven method is cheaper, works and will save you money- try it.
The website claims that the weight loss induced by Zyatrim is permanent because the fat cells are destroyed for ever. And what is astonishing is that it starts to work within one hour.
What is even more incredible is that this so called reputable company also has a whole page where it trashes every other weight loss pill. Not a very professional way to conduct a business. If Zyatrim worked, why not let it effectiveness do the talking? And just to add some more information- Zyatrim is not approved by the FDA.
The ingredients listed in Zyatrim are extracts of Acacia Rigidula. Acacia Rigidula is a tree which grows in Central America, including Mexico. For decades it was observed that this plant was eaten by the wild goats that never got fat. Other ingredients that have been extracted from this tree and included in the formulation include methylsynephrine, phenylethylamine, Cassis nomane, theobromine, Yohimbine and ECGC. This combination is said to reverse the weight gain.
What does Zyatrim cost?
A month’s supply of Zyatrim is only $50, of course the more you buy the bigger the discounts (if a pill worked that great, would any company sell it for less, especially a weight loss pill?).
Now to the facts. There is ZERO evidence that Zyatrim works. There are no clinical trials nor is there a single piece of scientific information which can back up claims made by the manufacturer of Zyatrim. In fact, all over cyberspace there are many individuals whose testimony counters what the manufacturers says. The refund policy is dubious and money is never refunded. The ingredients listed are nothing special. These ingredients have been around for centuries and asides from working like a caffeinated product do nothing else.
Does anyone really believe that the FDA would allow a weight loss product to be sold online without a prescription if the above listed ingredients listed were present? Despite reports that extracts of this tree contain potent alkaloids and other chemicals, these results have never been verified in a scientific laboratory and are considered to be a hoax. There is no mention of Zyatrim in any scientific research study.
The economy is difficult today and in such times there are always charlatans who prey on other people’s hopes and dreams. Zyatrim is not the pill you should take to lose weight. The plant, Acacia Rigidula., from which Zyatrim is derived, is best left for the wild goats in Mexico. In other words- it is CRAP.
If you want to lose weight, start walking more, eat less and avoid dubious products like Zyatrim. This proven method is cheaper, works and will save you money- try it.
Zyatrim: Another junk weight loss pill?
Over the past few decades, many new weight loss pills have come and gone. Each week there is a different pill or herb for weight loss. The claims are astonishing- weight loss in a day, permanent weight loss, lose 100 pounds in 4 weeks, look great, feel great, your booty will be gone in a week, your bum will disappear in 2 weeks and so on. There are so many pills and herbs- the whole weight loss industry has gone crazy. For the consumer desperate for weight loss this can be confusing, irritating and expensive. Which pill to try next is an ongoing task.
First, just the facts. Weight loss pills have been around for more than 50 years and more pills hand herbs have been developed in the past decade than at any other time in history. Obesity is not only an American problem,- even in Africa, a continent which has always been caught up with famine and drought has the obesity bug. And in each and every country, there are pills, creams and lotions- all the ads are same. Our pills are the best and most effective.
So do any of these pills work?
Fact -if any pill has worked or is working to decrease obesity, then it is pure chance. In this entire universe it is difficult to find more than 5-10 people who have gone on to lose weight by using over the counter weight loss pills.
So now we come to Zyatrim.
First, just the facts. Weight loss pills have been around for more than 50 years and more pills hand herbs have been developed in the past decade than at any other time in history. Obesity is not only an American problem,- even in Africa, a continent which has always been caught up with famine and drought has the obesity bug. And in each and every country, there are pills, creams and lotions- all the ads are same. Our pills are the best and most effective.
So do any of these pills work?
Fact -if any pill has worked or is working to decrease obesity, then it is pure chance. In this entire universe it is difficult to find more than 5-10 people who have gone on to lose weight by using over the counter weight loss pills.
So now we come to Zyatrim.
Thursday, April 9, 2009
Sibutramine- safe weight loss drug Part 2
Who cannot take Sibutramine?
Sibutramine is not indicated for all individuals. Individuals who have mental health problems should refrain from taking this drug as it may make the symptoms worse. Those individual with a history of high blood pressure can take the drug but should be closely monitored. Because the drug has not been fully evaluated in pregnancy, females anticipating getting pregnant or those who are breast-feeding should avoid Sibutramine.
What complications can occur with Sibutramine?
Over the years, there have been a few rare cases of heart attacks and kidney failure, which have caused concern in the medical community and FDA. It is important to note that the number of individuals who developed the complications were very small. All short-term studies have shown the drug to be safe.
How much Sibutramine does one take?
Sibutramine is generally taken once a day- the starting dose is usually 10 mg and this can be increased slowly by 5 mg/week until one sees a reduction in appetite. Doses as high as 60mg have been studied without any major side effects.
To be safe, it is important for all individuals taking sibutramine to be closely followed by a health care professional. Further, it is important not to take the drug for more than 2 months. If it has not worked by the end of 2 months, it is not likely to work if taken any longer. Taking it longer only increases the chance of complications.
Does Sibutramine work in everyone?
No, at best it works in about 60% of individuals. For those who intend to use Sibutramine, it is highly recommended that one also change the lifestyle, eat less, and enter an exercise program. These changes can help one sustain the weight loss achieved with Sibutramine.
Sibutramine is not indicated for all individuals. Individuals who have mental health problems should refrain from taking this drug as it may make the symptoms worse. Those individual with a history of high blood pressure can take the drug but should be closely monitored. Because the drug has not been fully evaluated in pregnancy, females anticipating getting pregnant or those who are breast-feeding should avoid Sibutramine.
What complications can occur with Sibutramine?
Over the years, there have been a few rare cases of heart attacks and kidney failure, which have caused concern in the medical community and FDA. It is important to note that the number of individuals who developed the complications were very small. All short-term studies have shown the drug to be safe.
How much Sibutramine does one take?
Sibutramine is generally taken once a day- the starting dose is usually 10 mg and this can be increased slowly by 5 mg/week until one sees a reduction in appetite. Doses as high as 60mg have been studied without any major side effects.
To be safe, it is important for all individuals taking sibutramine to be closely followed by a health care professional. Further, it is important not to take the drug for more than 2 months. If it has not worked by the end of 2 months, it is not likely to work if taken any longer. Taking it longer only increases the chance of complications.
Does Sibutramine work in everyone?
No, at best it works in about 60% of individuals. For those who intend to use Sibutramine, it is highly recommended that one also change the lifestyle, eat less, and enter an exercise program. These changes can help one sustain the weight loss achieved with Sibutramine.
Sibutramine- safe weight loss drug
Sibutramine also known as Meridia is a relatively drug to help individuals lose weight. The drug has been available in Europe for many years but has only been available in the USA for a few years.
How does it work?
Sibutramine acts by inhibiting the desire to eat. The drug enters the brain and inhibits the appetite center
How is the drug administered?
Sibutramine is available as a pill and taken daily for 1-2 months to have the desired results.
Does Sibutramine work?
Most definitely, it works and does reduce weight. However, the problem is that the drug does have a few undesirable side effects
How long can one take Sibutramine?
The drug is approved by the FDA for short-term use only and is generally safe if taken for that time period (usually less than 8 weeks). A number of large-scale clinical studies have concluded that short-term use of Sibutramine is safe. It is only when the drug is taken for many months that the side effects become prevalent.
How much weight can one lose on Sibutramine?
Most people who have taken sibutramine notice a weight loss of anywhere from 10-12 pounds over 6-8 weeks.
What are the side effects of Sibutramine?
The most common side effects of the drug include the following:
- dry mouth
- nausea
- metallic or acid taste in the mouth
- abdominal cramps, bloating,
- stomach pain
- headaches
- joint pains
- facial flushing
- increased blood pressure
- chest palpitations
- mood changes like depression,, anxiety
- chest pain
- shortness of breath
Not everyone develops these side effects. European studies indicate that about one in a hundred individuals may develop one or more of the above side effects. All the side effects disappear when the drug is discontinued
How does it work?
Sibutramine acts by inhibiting the desire to eat. The drug enters the brain and inhibits the appetite center
How is the drug administered?
Sibutramine is available as a pill and taken daily for 1-2 months to have the desired results.
Does Sibutramine work?
Most definitely, it works and does reduce weight. However, the problem is that the drug does have a few undesirable side effects
How long can one take Sibutramine?
The drug is approved by the FDA for short-term use only and is generally safe if taken for that time period (usually less than 8 weeks). A number of large-scale clinical studies have concluded that short-term use of Sibutramine is safe. It is only when the drug is taken for many months that the side effects become prevalent.
How much weight can one lose on Sibutramine?
Most people who have taken sibutramine notice a weight loss of anywhere from 10-12 pounds over 6-8 weeks.
What are the side effects of Sibutramine?
The most common side effects of the drug include the following:
- dry mouth
- nausea
- metallic or acid taste in the mouth
- abdominal cramps, bloating,
- stomach pain
- headaches
- joint pains
- facial flushing
- increased blood pressure
- chest palpitations
- mood changes like depression,, anxiety
- chest pain
- shortness of breath
Not everyone develops these side effects. European studies indicate that about one in a hundred individuals may develop one or more of the above side effects. All the side effects disappear when the drug is discontinued
Monday, April 6, 2009
Xenical (AKA Orlistat) – a good weight loss pill? Part 2
What is alli?
Alli is a brand name of Orlistat and available without a prescription. Alli is only half the prescription strength of Orlistat. Two pills of alli equal one Orlistat pill
How effective is Orlistat?
Well, it is an effective drug for weight loss. The weight loss usually occurs gradually over a period of 2-3 months.
Does Orlistat work in everyone?
No, for some unknown reason it only works in less than 40% of individuals. Asians, Orientals and Africans appear to have a genetic difference in the enzyme, lipase. The enzyme is not effectively inhibited by Orlistat in this patient population.
What else can one do to lose weight?
Orlistat is not the magic pill for weight loss and one also needs to eat less, and enter an exercise program
How much weight can one lose with Orlistat?
Most people claim that they lose 10-15 pounds over 4-6 months. Long term use does not seem to increase this weight loss
What is the dose of Orlistat?
The dose of prescription Orlistat is 120 mg and is supposed to be taken I hr before each meal.
What else should I know about Orlistat?
Because a few vitamins need fat to be absorbed in the blood stream, Orlistat use can prevent absorption of vitamins A, D, E, and K. Thus, one has to take supplements of these enzymes. Never take the vitamins supplements at the same time as Orlistat- they will simply be eliminated in the poop.
What are side effects of Orlistat?
Orlistat is a safe drug but has unpleasant side effects. It is because of the side effects that most people cannot take Orlistat for long periods. Passage of fat into the bowels lead to a lot of gas, abdominal cramps, frothy and oily stool. Plus, the oily stools often leak out of the anus and soil the under pants.
These side effects are less when the drug is not taken every day. The side effects do resolve when the pill is stopped. Some people wear diapers during this time to avoid repeated soilage of their underwear
What is cost of the Orlistat?
Orlistat is fairly expensive. Each pill can cost anywhere from $2-$3. One needs to take each pill 3 times a day. This can amount to about $200-$300 a month. This may sound a lot but bariatric surgery can cost $15,000-$25,000.
Final advice
Do not take Orlistat which requires a prescription and is expensive.. If you want to lose weight, take alli which is the same pill, costs much less and one does not need a prescription. Alli is available at half the strength and works just as well
Alli is a brand name of Orlistat and available without a prescription. Alli is only half the prescription strength of Orlistat. Two pills of alli equal one Orlistat pill
How effective is Orlistat?
Well, it is an effective drug for weight loss. The weight loss usually occurs gradually over a period of 2-3 months.
Does Orlistat work in everyone?
No, for some unknown reason it only works in less than 40% of individuals. Asians, Orientals and Africans appear to have a genetic difference in the enzyme, lipase. The enzyme is not effectively inhibited by Orlistat in this patient population.
What else can one do to lose weight?
Orlistat is not the magic pill for weight loss and one also needs to eat less, and enter an exercise program
How much weight can one lose with Orlistat?
Most people claim that they lose 10-15 pounds over 4-6 months. Long term use does not seem to increase this weight loss
What is the dose of Orlistat?
The dose of prescription Orlistat is 120 mg and is supposed to be taken I hr before each meal.
What else should I know about Orlistat?
Because a few vitamins need fat to be absorbed in the blood stream, Orlistat use can prevent absorption of vitamins A, D, E, and K. Thus, one has to take supplements of these enzymes. Never take the vitamins supplements at the same time as Orlistat- they will simply be eliminated in the poop.
What are side effects of Orlistat?
Orlistat is a safe drug but has unpleasant side effects. It is because of the side effects that most people cannot take Orlistat for long periods. Passage of fat into the bowels lead to a lot of gas, abdominal cramps, frothy and oily stool. Plus, the oily stools often leak out of the anus and soil the under pants.
These side effects are less when the drug is not taken every day. The side effects do resolve when the pill is stopped. Some people wear diapers during this time to avoid repeated soilage of their underwear
What is cost of the Orlistat?
Orlistat is fairly expensive. Each pill can cost anywhere from $2-$3. One needs to take each pill 3 times a day. This can amount to about $200-$300 a month. This may sound a lot but bariatric surgery can cost $15,000-$25,000.
Final advice
Do not take Orlistat which requires a prescription and is expensive.. If you want to lose weight, take alli which is the same pill, costs much less and one does not need a prescription. Alli is available at half the strength and works just as well
Xenical (AKA Orlistat) – a good weight loss pill?
What is Xenical?
In the last 40 years many weight loss pills have been developed. The majority have been derivatives of the addictive drug, amphetamine. While these drugs have been effective, they also have had serious side effects including physical dependence. Now there is a new weight loss pill known as Orlistat (Xenical).
How is it administered?
Xenical is available as a prescription pill and can help one reduce weight.
How does it work?
Orlistat works by preventing absorption of fat from the intestine. For a normal person, before fat can be absorbed into the blood stream, it has to be broken down into smaller fragments by an enzyme in the intestine. This enzyme, lipase, is blocked by Orlistat. Once the enzyme is blocked, any ingested fat is simply excreted into the feces. The maximum inhibition of the enzyme by Orlistat is not 100 percent but ranges anywhere from 50%-80%
What happens to the fat one eats?
Because the fat is no longer broken down, it is excreted and appears in the stools. The stools appear frothy, bulky and have a distinct smell. The stools also appear greasy and can fill up the entire toilet because of the froth.
When does one take the pill?
Orlistat is best taken at least an hour before a fatty meal. If you are not going to eat fat, there is no point in taking the pill
In the last 40 years many weight loss pills have been developed. The majority have been derivatives of the addictive drug, amphetamine. While these drugs have been effective, they also have had serious side effects including physical dependence. Now there is a new weight loss pill known as Orlistat (Xenical).
How is it administered?
Xenical is available as a prescription pill and can help one reduce weight.
How does it work?
Orlistat works by preventing absorption of fat from the intestine. For a normal person, before fat can be absorbed into the blood stream, it has to be broken down into smaller fragments by an enzyme in the intestine. This enzyme, lipase, is blocked by Orlistat. Once the enzyme is blocked, any ingested fat is simply excreted into the feces. The maximum inhibition of the enzyme by Orlistat is not 100 percent but ranges anywhere from 50%-80%
What happens to the fat one eats?
Because the fat is no longer broken down, it is excreted and appears in the stools. The stools appear frothy, bulky and have a distinct smell. The stools also appear greasy and can fill up the entire toilet because of the froth.
When does one take the pill?
Orlistat is best taken at least an hour before a fatty meal. If you are not going to eat fat, there is no point in taking the pill
Sunday, April 5, 2009
Is there a drug(s) to halt dementia in patients with Alzheimer's?
In the last decade a number of medications have been developed to reverse/halt the effects of dementia. One of the most common disorders associated with dementia world wide is Alzheimer’s. This awful disease generally starts around the age 70 and progresses relentlessly. Now drug companies are marketing drugs to help halt or reverse the dementia . The first such drug used to reverse dementia was Aricept. Since then, a variety of other nootropic drugs have been developed including donepezil, galantamine, and rivastigmine. A number of clinical studies have been done comparing these drugs to placebo in patients with Alzheimer’s.
In all the studies, only the mildest cases of Alzheimer’s dementia was improved with these drugs. Further, there was no difference between the drugs. The most clear finding from these trials was that these drugs had significant side effects and close to 30-50 percent of patients had to discontinue the drugs.
At the moment, these nootropic drugs have not been the panacea for treatment of dementia. These drugs do not work in all types of dementia except Alzheimer’s. And even when the drugs work, only the mild cases of Alzheimer’s disease improves. Finally, these drugs are fairly expensive and not everyone responds to them. Less than 5 percent of patient show any significant improvement.
So what is the consumer supposed to do? Most experts do not recommend these drugs because of the profound side effects which makes the individual worse than he/she previously was. Further these medications have to be taken every day and do not cure Alzheimer’s disease. The beneficial effects of these drugs are not long lasting and stop the moment the drug is discontinued.
The decision of whether to start drug therapy to reverse or halt dementia is personal and requires some clinical judgment. Unfortunately so far no drug has made any great impact on the disease. As of today, loving and supportive care of your family member is still better than any drug therapy for Alzheimer’s disease
In all the studies, only the mildest cases of Alzheimer’s dementia was improved with these drugs. Further, there was no difference between the drugs. The most clear finding from these trials was that these drugs had significant side effects and close to 30-50 percent of patients had to discontinue the drugs.
At the moment, these nootropic drugs have not been the panacea for treatment of dementia. These drugs do not work in all types of dementia except Alzheimer’s. And even when the drugs work, only the mild cases of Alzheimer’s disease improves. Finally, these drugs are fairly expensive and not everyone responds to them. Less than 5 percent of patient show any significant improvement.
So what is the consumer supposed to do? Most experts do not recommend these drugs because of the profound side effects which makes the individual worse than he/she previously was. Further these medications have to be taken every day and do not cure Alzheimer’s disease. The beneficial effects of these drugs are not long lasting and stop the moment the drug is discontinued.
The decision of whether to start drug therapy to reverse or halt dementia is personal and requires some clinical judgment. Unfortunately so far no drug has made any great impact on the disease. As of today, loving and supportive care of your family member is still better than any drug therapy for Alzheimer’s disease
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